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Is Allergen Immunotherapy in Children Disease Modifying? A Review of the Evidence

  • Immunotherapy and Immunomodulators (B Vickery, Section Editor)
  • Published:
Current Allergy and Asthma Reports Aims and scope Submit manuscript

Abstract

Purpose of Review

Although evidence supports a beneficial effect of allergen immunotherapy on the symptoms of allergic respiratory disease and food allergy, it is not clear whether immunotherapy modifies the natural history of these conditions.

Recent Findings

In aeroallergen immunotherapy, studies suggest that prevention of asthma can be attained. Less evident is the ability of immunotherapy to prevent new allergen sensitizations and more studies are needed to test whether immunotherapy can continue suppressing airway symptoms after treatment discontinuation. In food allergen immunotherapy, there is evidence that unresponsiveness to a food challenge can be sustained in some treatment recipients, but little knowledge exists as to the dose and duration of treatment that can optimize this effect.

Summary

Suggestive evidence exists that allergen immunotherapy can modify allergic disease in children, but definitive studies are lacking. More research in the field is required.

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  1. Division of Allergy, Immunology and Transplantation, Allergy, Asthma and Airway Biology Branch, National Institute of Allergy and Infectious Diseases, NIH, 5601 Fishers Lane, Rockville, MD, 20892, USA

    Amanda K. Rudman Spergel, Michael Minnicozzi, Lisa M. Wheatley & Alkis Togias

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  1. Amanda K. Rudman Spergel
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Correspondence to Amanda K. Rudman Spergel.

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Dr. Togias is Chief of the NIAID/DAIT Branch that has funded several of the studies cited in this review. The other authors declare no conflicts of interest relevant to this manuscript.

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This article does not contain any studies with human or animal subjects performed by any of the authors.

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This article is part of the Topical Collection on Immunotherapy and Immunomodulators

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Rudman Spergel, A.K., Minnicozzi, M., Wheatley, L.M. et al. Is Allergen Immunotherapy in Children Disease Modifying? A Review of the Evidence. Curr Allergy Asthma Rep 18, 47 (2018). https://doi.org/10.1007/s11882-018-0801-y

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