Food-Induced Anaphylaxis: an Update

  • Christopher P. Parrish
  • Heidi Kim
Anaphylaxis and Drug Allergy (DA Khan and M Castells, Section Editors)
Part of the following topical collections:
  1. Topical Collection on Anaphylaxis and Drug Allergy


Purpose of Review

This review aims to provide an update of recent advances in the epidemiology, clinical features and diagnosis, and management of food-induced anaphylaxis (FIA).

Recent Findings

Food allergy prevalence and FIA rates continue to rise, but FIA fatalities are stable. Basophil and mast cell activation tests promise more accurate identification of food triggers. Oral, sublingual, and epicutaneous immunotherapy can desensitize a significant portion of subjects. Epinephrine use for FIA remains sub-optimal.


As the burden of food allergy continues to increase, it appears that the corresponding increase in research focused on this epidemic is beginning to bear fruit. The stable number of FIA fatalities in the face of an ongoing epidemic indicates lives have already been saved. The emergence of new diagnostic tests and interventional therapies may transform the management of FIA in the coming years.


Food allergy Anaphylaxis Epinephrine Peanut allergy Oral immunotherapy 


Compliance with Ethical Standards

Conflict of Interest

Dr. Parrish reports personal fees and non-financial support from Pharmacy Times Continuing Education, non-financial support from DBV Technologies, and non-financial support from Aimmune Therapeutics, outside the submitted work. Dr. Kim declares that she has no conflict of interest.

Human and Animal Rights and Informed Consent

This article does not contain any studies with human or animal subjects performed by any of the authors.


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© Springer Science+Business Media, LLC, part of Springer Nature 2018

Authors and Affiliations

  1. 1.Department of Pediatrics and Internal Medicine, Division of Allergy and ImmunologyUniversity of Texas Southwestern Medical SchoolDallasUSA
  2. 2.Department of PediatricsUniversity of Texas Southwestern Medical SchoolDallasUSA

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