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Nanotechnologies for In Vitro IgE Testing

  • Immunologic/Diagnostic Tests in Allergy (M Chapman and A Pomés, Section Editors)
  • Published:
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Abstract

Purpose of Review

This review discusses the recent advances in the development of IgE antibody assays based on nanotechnologies. IgE blood testing is an important part of the diagnostic workup of IgE-mediated hypersentivity. We also address the challenges in moving from an academic proof-of-concept to a product routinely used by allergy experts.

Recent Findings

Several nanotechnologies have been applied to the field of IgE testing: nanoparticles are used either as a support to capture analytes or as a detection tool to enhance the measurement signal. Nanofluidics allows to reduce assay time by enhancing molecular interaction.

Summary

Nanotechnologies bring forth new methods for in vitro IgE testing. Substantial advantages such as lower sample volume, shorter assay time, simplified procedures, and lower analytic sensitivity, without affecting test precision and accuracy, can be achieved thanks to nanotechnologies.

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Authors and Affiliations

  1. Abionic SA, Biopôle, sect. Esplanade SE-A, Route de la Corniche 3, CH-1066, Epalinges, Switzerland

    Iwan Märki &  Fabien Rebeaud

Authors
  1. Iwan Märki
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  2. Fabien Rebeaud
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Correspondence to Iwan Märki.

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Conflict of Interest

The first author has a patented nanofluidic biosensor and its use for rapid measurement of biomolecular interactions in solution and methods issued; a patented apparatus and method for detecting and measuring biomolecular interactions; and is one of the inventors of the nanofluidic technology described in the text.

Human and Animal Rights and Informed Consent

This article does not contain any studies with human or animal subjects performed by any of the authors.

Additional information

This article is part of the Topical Collection on Immunologic/Diagnostic Tests in Allergy

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Märki, I., Rebeaud, . Nanotechnologies for In Vitro IgE Testing. Curr Allergy Asthma Rep 17, 50 (2017). https://doi.org/10.1007/s11882-017-0717-y

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  • DOI: https://doi.org/10.1007/s11882-017-0717-y

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