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Management of Skin Cancer in the High-Risk Patient

  • Skin Cancer (BY Kwong, Section Editor)
  • Published:
Current Treatment Options in Oncology Aims and scope Submit manuscript

Opinion Statement

Skin cancer is the most common of human cancers and outnumbers all other types of cancer combined in the USA by over threefold. The majority of non-melanoma skin cancers are easily treated with surgery or locally destructive techniques performed under local anesthesia in the cost-effective outpatient setting. However, there is a subset of “high-risk” cases that prove challenging in terms of morbidity, mortality, adjuvant treatment required, as well as overall cost to the health care system. In our opinion, the term “high risk” when applied to skin cancer can mean one of three things: a high-risk tumor with aggressive histologic and/or clinical features with an elevated risk for local recurrence or regional/distant metastasis, a high-risk patient with the ongoing development of multiple skin cancers, and a high-risk patient based on immunosuppression. We have recently proposed classifying NMSC as a chronic disease in a certain subset of patients. Although no consensus definition exists for a chronic disease in medicine, there are three components that are present in most definitions: duration of at least 1 year, need for ongoing medical care, and functional impairment and/or alteration of activities of daily living (ADLs) and quality of life (QOL). Immunosuppression can refer to exogenous (organ or stem cell transplant patients,) or endogenous (HIV, leukemia, lymphoma, genodermatoses with DNA mismatch repair problems or other immunosuppression) causes. These patients are at risk for high-risk tumors and/or the development of multiple tumors.

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Authors and Affiliations

  1. Keck School of Medicine of USC, 1441 Eastlake Ave, Ezralow Tower, Suite 5301, Los Angeles, CA, 90033-9176, USA

    James W. Behan MD, Adam Sutton MD, MBA & Ashley Wysong MD, MS

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  1. James W. Behan MD
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  2. Adam Sutton MD, MBA
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  3. Ashley Wysong MD, MS
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Correspondence to Ashley Wysong MD, MS.

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James W. Behan, Adam Sutton, and Ashley Wysong declare that they have no conflict of interest.

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This article does not contain any studies with human or animal subjects performed by any of the authors.

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This article is part of the Topical Collection on Skin Cancer

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Behan, J.W., Sutton, A. & Wysong, A. Management of Skin Cancer in the High-Risk Patient. Curr. Treat. Options in Oncol. 17, 60 (2016). https://doi.org/10.1007/s11864-016-0435-z

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