The therapeutic effect of ultraviolet (UV) light is generally attributed to its immunosuppressive and immunomodulatory effects. Since chronic inflammation is the major factor in the development of nasal polyposis, we have previously used mixed ultraviolet-visible light (mUV-VIS, Rhinolight®) phototherapy for the treatment of nasal polyps.
In the present open, multicenter study, our aim was to delineate whether mUV-VIS applied postoperatively in vivo together with intranasal steroid treatment could reduce the recurrence of nasal polyps.
After functional endoscopic sinus surgery, one group of patients received mUV-VIS light together with standard intranasal steroid (mometason furoate 2 × 200 μg) application for a 12-week treatment period, whereas the other patient group obtained only intranasal steroid for the same duration. We recorded nasal endoscopy images and obtained demographical and clinical data, total nasal score (TNS), and nasal obstruction symptom evaluation (NOSE). We performed acoustic rhinometry and measured nasal inspiratory peak flow. Follow-up was 12 months.
We found that the recurrence of nasal polyps was significantly diminished, and based on video-endoscopic measurements, the size and grade of recurrent polyps were significantly smaller in the phototherapy-receiving group. Nasal obstruction values and NOSE were significantly better throughout the follow-up period in the mUV-VIS light-treated group than in the intranasal steroid monotreatment group.
Rhinophototherapy together with standard nasal steroid application may have a supportive role in the treatment of recurrent bilateral nasal polyps.
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Availability of data and materials
The datasets used and/or analyzed during the current study are available from the corresponding author on reasonable request.
Chronic rhinosinusitis without nasal polyps
Chronic rhinosinusitis with nasal polyps
Eosinophil cationic protein
Functional endoscopic sinus surgery
Mixed ultraviolet-visible light
Narrow-band UV light
Nasal inspiratory peak flow
Nasal obstruction symptom evaluation
Total nasal score
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This work was funded by the Jedlik Ányos Program NKP-07-A1-ORLPOLYP-hu (OM-00033-36/2008).
Ethics approval and consent to participate
The study was approved by The Ethics Committee of the University of Szeged, Hungary. All patients gave informed consents. The scheme of the experiments complies with the ethics of research and agrees with the declaration of the Medical World Federation proclaimed in Helsinki in 1964. Human Investigation Board of the University of Szeged #159/2010.
Consent for publication
All the authors have read the manuscript and approved its submission.
The authors declare that they have no competing interests.
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Kiricsi, Á., Kiricsi, M., Szabó, Z. et al. Open, prospective, multicenter study on postoperative intranasal phototherapy in nasal polyposis. Ir J Med Sci (2021). https://doi.org/10.1007/s11845-021-02518-1
- Intranasal phototherapy
- Mixed UV-visible light
- Nasal polyposis
- Postoperative treatment
- Recurrence prevention