Open, prospective, multicenter study on postoperative intranasal phototherapy in nasal polyposis

Abstract

Background

The therapeutic effect of ultraviolet (UV) light is generally attributed to its immunosuppressive and immunomodulatory effects. Since chronic inflammation is the major factor in the development of nasal polyposis, we have previously used mixed ultraviolet-visible light (mUV-VIS, Rhinolight®) phototherapy for the treatment of nasal polyps.

Aims

In the present open, multicenter study, our aim was to delineate whether mUV-VIS applied postoperatively in vivo together with intranasal steroid treatment could reduce the recurrence of nasal polyps.

Methods

After functional endoscopic sinus surgery, one group of patients received mUV-VIS light together with standard intranasal steroid (mometason furoate 2 × 200 μg) application for a 12-week treatment period, whereas the other patient group obtained only intranasal steroid for the same duration. We recorded nasal endoscopy images and obtained demographical and clinical data, total nasal score (TNS), and nasal obstruction symptom evaluation (NOSE). We performed acoustic rhinometry and measured nasal inspiratory peak flow. Follow-up was 12 months.

Results

We found that the recurrence of nasal polyps was significantly diminished, and based on video-endoscopic measurements, the size and grade of recurrent polyps were significantly smaller in the phototherapy-receiving group. Nasal obstruction values and NOSE were significantly better throughout the follow-up period in the mUV-VIS light-treated group than in the intranasal steroid monotreatment group.

Conclusions

Rhinophototherapy together with standard nasal steroid application may have a supportive role in the treatment of recurrent bilateral nasal polyps.

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Availability of data and materials

The datasets used and/or analyzed during the current study are available from the corresponding author on reasonable request.

Abbreviations

ARM:

Acoustic rhinometry

CRS:

Chronic rhinosinusitis

CRSsNP:

Chronic rhinosinusitis without nasal polyps

CRSwNP:

Chronic rhinosinusitis with nasal polyps

CT:

Computed tomography

DNA:

Deoxyribonucleic acid

ECP:

Eosinophil cationic protein

FESS:

Functional endoscopic sinus surgery

IL-5:

Interleukin-5

mUV-VIS:

Mixed ultraviolet-visible light

NB-UVB:

Narrow-band UV light

NIPF:

Nasal inspiratory peak flow

NOSE:

Nasal obstruction symptom evaluation

PND:

Post-nasal drip

TNS:

Total nasal score

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Funding

This work was funded by the Jedlik Ányos Program NKP-07-A1-ORLPOLYP-hu (OM-00033-36/2008).

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Affiliations

Authors

Contributions

ÁK, MK, and BZS interpreted the results and drafted the manuscript, ÁK, BZS, ZSSZ, and EK performed the visits and acquired the data; LK and EK conceived the work. ÉDR and MK performed statistical analysis. FI developed instruments used in the study. LK, EK, and LR coordinated the related research activities and supervised all experiments. All authors revised and approved the final version of the manuscript.

Corresponding author

Correspondence to Ágnes Kiricsi.

Ethics declarations

Ethics approval and consent to participate

The study was approved by The Ethics Committee of the University of Szeged, Hungary. All patients gave informed consents. The scheme of the experiments complies with the ethics of research and agrees with the declaration of the Medical World Federation proclaimed in Helsinki in 1964. Human Investigation Board of the University of Szeged #159/2010.

Consent for publication

All the authors have read the manuscript and approved its submission.

Competing interests

The authors declare that they have no competing interests.

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Cite this article

Kiricsi, Á., Kiricsi, M., Szabó, Z. et al. Open, prospective, multicenter study on postoperative intranasal phototherapy in nasal polyposis. Ir J Med Sci (2021). https://doi.org/10.1007/s11845-021-02518-1

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Keywords

  • Intranasal phototherapy
  • Mixed UV-visible light
  • Nasal polyposis
  • Postoperative treatment
  • Recurrence prevention