Abstract
The differences among the antimicrobial activities of synthetic nanoparticles (NPs), organic agents and conventional antibiotics against human pathogens are little known. We compared the antimicrobial activities of aqueous, ethanol and ethyl acetate extracts of Zingiber officinale rhizomes with ZnS NPs and tetracycline/nystatin using agar-diffusion techniques. Transmission electron microscopy (TEM), Fourier transform infrared (FTIR) and ultraviolet spectroscopy were used to characterize ZnS NPs. At 100 mg/ml, ethanol and ethyl acetate extract inhibited Acinetobacter baumannii, Salmonella typhimurium, Enterococcus faecium, Shigella flexneri, Klebsiella pneumoniae, Staphylococcus epidermidis and Candida albicans with zones of inhibition (ZOI) ranging between 0–42 mm and 0–39 mm, respectively. Candida albicans had a remarkable ZOI of 42 mm and 22 mm from ethanol and ZnS NPs compared with 20 mm from conventional nystatin. TEM and FTIR revealed spherically shaped polydispersed NPs with particle size of 12.5 nm and the role of banana peel extracts in ZnS NPs synthesis. Organic and synthetic NPs proved potential alternatives to conventional antimicrobial agents.
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A. Nick, T. Rali, and O. Sticher, J. Ethnopharmacol. 49, 147 (1995).
K.O. Akinyemi, O. Oladapo, C.E. Okwara, C.C. Ibe, and K.A. Fasure, BMC Complement. Altern. Med. 5, 1 (2005).
J.H. Doughari, Trop. J. Pharm. Res. 5, 597 (2006).
J. Calixto, Braz. J. Med. Biol. Res. 33, 179 (2000).
C.W. Fennel, K.L. Lindsey, L.J. McGaw, O.M. Grace, and J. VanStaden, J. Ethnopathol. 94, 205 (2004).
R.A. Street, W.A. Stirk, and J. VanStaden, J. Ethnopharmacol. 119, 205 (2008).
A. Nostro, M.P. Germano, V.D. Angelo, A. Marino, and M.A. Cannatelli, Lett. Appl. Microbiol. 30, 379 (2000).
A. Samie, C.L. Obi, P.O. Bessong, and L. Namrita, Afr. J. Biotechnol. 4, 1443 (2005).
D.A. Akinpelu and T.M. Onakoya, Afr. J. Biotechnol. 5, 1078 (2006).
J. Parekh and S. Chanda, Afr. J. Biotechnol. 6, 766 (2007).
M.I. Okeke, C.U. Iroegbu, C.O. Jideofor, A. Okoli, and C.O. Esimone, J. Herb spices Med. Plants 8, 39 (2001).
U.J.J. Ijah and F.O. Oyebanji, Glob. J. Pure Appl. Sci. 9, 193 (2003).
A.O. Ogundare, F.C. Adetuyi, and F.A. Akinyosoye, Afr. J. Biotechnol. 5, 1663 (2006).
H. White, Medicine and Wart Removal, Hemorrhoids Treatment and Herpes Prevention Without Drugs (McGraw-Hill, New York, 2006). pp. 102–105.
R.N. Okigbo and M. Igwe, Acta Microbiol. Immunol. Hung. 54, 353 (2007).
A.M. Oloyede, A.O. Aduramigba-Modupe, and I.K. Efem, Nat. Sci. 10, 43 (2012).
D.K. Olukoya, N. Idika, and T. Odugbemi, J. Ethnopharmacol. 39, 69 (1993).
R.A. Onyeagba, O.C. Ugbogu, C.U. Okeke, and O. Iroakasi, Afr. J. Biotechnol. 3, 552 (2004).
S.A. Sakir and W.M. Al-Amoudi, J. Appl. Pharm. Sci 02, 22 (2012).
F.O. Omoya and F.C. Akharaiyi, Int. Res. J. Pharm. 2, 127 (2012).
Z.M. Al-Amin, Br. J. Nutr. 96, 660 (2006).
A.T. Afshari, Food Chem. 101, 148 (2007).
A. Sebiomo, A.D. Awofodu, A.O. Awosanya, F.E. Awotona, and A.J. Ajayi, J. Microbiol. Antimicrob. 3, 18 (2011).
P.N. Ravindran and K. Nirmal Babu, Botany and Crop Improvement of Ginger—The Genus Zingiber (CRC Press, 2005).
A. Cakir, S. Kordali, H. Zengin, S. Izumi, and T. Hirata, Flavour Frag. J. 19, 62 (2004).
E.E. Elgorashi, J.L.S. Taylor, A. Maes, M. deKimpe, J. VanStaden, and L. Verschaeve, S. Afr. J. Bot. 68, 408 (2002).
N.S. Mashhadi, R. Ghiasvand, G. Askari, M. Hariri, L. Darvishi, and M. Rezamofid, Int. J. Prev. Med. 4, S36 (2013).
C.O. Eleazu, K.C. Eleazu, E. Awa, and S.C. Chukwuma, Eur. J. Biotechnol. Pharm. Res. 3, 42 (2012).
S. Nair, A. Sasidharan, V.V.V.D. Rani, D. Menon, S. Nair, K. Mazoor, and S. Raina, J. Mater. Sci. Mater. Med. 20, 235 (2009).
N. Padmavati and R. Vijayaraghavan, Sci. Technol. Adv. Mater. 9, 1468 (2008).
R. Hardman, Environ. Health Perspect. 114, 165 (2006).
S.P. Malu, G.O. Obochi, E.N. Tawo, and B.E. Nyong, Glob. J. Pure Appl. Sci. 15, 365 (2009).
G.E. Treese and W.C. Evans, Pharmacognosy (London: Bailliere Tridall, 1996), pp. 89–122.
B.A. Forbes, D.F. Sahm, A.S. Weissfeld, and E.A. Trevino, Bailey Scott’s diagnostic microbiology, ed. E.J. Baron, L.R. Peterson, and S.M. Finegold (St Louis: Mosby Co., 1990), pp. 171–194.
S. Omar, B. Lemonnier, N. Jones, C. Ficker, M.L. Smith, C. Neema, G.H.W. Towers, K. Goel, and J.T. Amason, J. Ethnopharmacol. 73, 161 (2000).
M.N. Igwo-Ezikpe, N.O.A. Imaga, H.A. Ogbunugafor, A.A. Osuntoki, S. Adeleye, and A.O. Ipadeola, The Bioscientist 1, 73 (2013).
M. Durandurdu, J. Phys. Chem. Solids 70, 645 (2009).
H.M.M. Ibrahim, J. Radiat. Res. Appl. Sci. 8, 265 (2015).
G.D. Lutterodt, A. Ismail, R.H. Basheer, and H.M. Baharudin, Malays. J. Med. Sci. 6, 17 (1999).
M.C. Marjorie, Clin. Microbiol. Rev. 12, 564 (1999).
S. Gur, D. Turgut-Balik, and N. Gur, World J. Agric. Sci. 2, 439 (2006).
G. Singh and S.V. Bhat, J. Appl. Phy. 111, 123913 (2012).
C. Malarkodi, S. Rajeshkumar, K. Paulkumar, G. GnanaJobitha, M. Vanaja, and G. Annadurai, Adv. Nanores. 1, 83 (2013).
D. Kim, S. Jeong, and J. Moon, Nanotechnology 17, 4019 (2006).
M. Vanaja, G. Gnanajobitha, K. Paulkumar, S. Rajeshkumar, C. Malarkodi, and G. Annadurai, J. Nanostruct. Chem. 3, 1 (2013).
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Obidi, O.F., Nejo, A.O., Ayeni, R.A. et al. Insights into Comparative Antimicrobial Efficacies of Synthetic and Organic Agents: The Case of ZnS Nanoparticles and Zingiber officinale Rosc.. JOM 70, 982–987 (2018). https://doi.org/10.1007/s11837-018-2816-1
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DOI: https://doi.org/10.1007/s11837-018-2816-1