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pH-triggered intracellular release of doxorubicin from polyaspartamide-encapsulated mesoporous silica nanoparticles

  • Polymer, Industrial Chemistry
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Abstract

Mesoporous silica nanoparticles (MSNs) conjugating doxorubicin (DOX) via a pH-sensitive cleavable linkage, hydrazine (HYD) were synthesized. MSN-HYD-DOX were encapsulated with the polyaspartamide (PASPAM) grafted with the hydrophilic o-(2-aminoethyl)-o′-methylpoly(ethylene glycol) (PEG) and the cell permeating ligand, biotin (Biotin). The chemical structure of the synthesized MSN-HYD-DOX and PASPAM-g-PEG/Biotin was confirmed using FT-IR and 1H-NMR spectroscopy. The mean diameter of the MSN-HYD-DOX@PASPAM-g-PEG/Biotin nanoparticle was 142 nm and 121 nm, respectively, examined by dynamic light scattering (DLS) and transmission electron microscope (TEM). The HYD bond was effectively cleaved in acidic condition, and thus DOX was released much faster at pH 5.0 than at pH 7.4. The cell viability in MSN-HYD-DOX@PASPAM-g-PEG/Biotin system was much lower than that of the free DOX drug because of efficient intracellular drug delivery associated with the biotin ligand.

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Authors and Affiliations

  1. School of Chemical Engineering, Sungkyunkwan University, Suwon, Gyeonggi, 16419, Korea

    Cheolwon Lim & Dukjoon Kim

  2. Department of Fine Chemistry, Seoul National University of Science and Technology, Seoul, 01811, Korea

    Eun-Bum Cho

Authors
  1. Cheolwon Lim
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  2. Eun-Bum Cho
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  3. Dukjoon Kim
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Correspondence to Dukjoon Kim.

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Lim, C., Cho, EB. & Kim, D. pH-triggered intracellular release of doxorubicin from polyaspartamide-encapsulated mesoporous silica nanoparticles. Korean J. Chem. Eng. 36, 166–172 (2019). https://doi.org/10.1007/s11814-018-0185-7

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  • DOI: https://doi.org/10.1007/s11814-018-0185-7

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