Agomelatine co-crystals with resorcinol and hydroquinone: Preparation and characterization

  • Min-Jeong Lee
  • Nan-Hee Chun
  • Hyo-Cheol Kim
  • Moon-Jip Kim
  • Paul Kim
  • Min-Yong Cho
  • Guang Jin Choi
Research papers

Abstract

We prepared and characterized co-crystals of the antidepressant drug agomelatine with pharmaceutically acceptable coformers for enhanced solubility. A novel agomelatine-resorcinol (AGO-RES, 2: 1) co-crystal was synthesized and its crystal structure was confirmed via single crystal X-ray diffraction. The AGO-RES co-crystal structure was created through the O-H∙∙∙O and N-H∙∙∙O hydrogen bonding between the phenolic OH of RES and the amide group of AGO. The chemical structure of two AGO co-crystals was characterized by FT-IR and Raman spectroscopies, whereas the solution behavior was determined by the intrinsic dissolution rate. When tested in water, both AGORES and AGO-HYQ form-I co-crystals showed higher apparent solubility than pure AGO. But the resulting AGO solution in a supersaturated state partially precipitated into specific crystal forms of AGO. As anticipated, the intrinsic dissolution rate of AGO was substantially enhanced by the co-crystal forms, which signifies that the bioavailability of AGO can be increased via co-crystal formulation approach.

Keywords

Co-crystal Agomelatine Resorcinol Hydroquinone Solubility 

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Copyright information

© Korean Institute of Chemical Engineers, Seoul, Korea 2018

Authors and Affiliations

  • Min-Jeong Lee
    • 1
  • Nan-Hee Chun
    • 2
  • Hyo-Cheol Kim
    • 3
  • Moon-Jip Kim
    • 3
  • Paul Kim
    • 4
  • Min-Yong Cho
    • 4
  • Guang Jin Choi
    • 4
    • 5
  1. 1.Crystallization and Particle Science, Institute of Chemical and Engineering Sciences, A*STAR (Agency for Science Technology and Research)Jurong IslandSingapore
  2. 2.Unimed Pharm Inc.Asan, ChungnamKorea
  3. 3.Department of PhysicsSoonchunhyang UniversityAsan, ChungnamKorea
  4. 4.Department of Pharmaceutical EngineeringSoonchunhyang UniversityAsan, ChungnamKorea
  5. 5.Department of Medical ScienceSoonchunhyang UniversityAsan, ChungnamKorea

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