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Clinicopathologic characteristics of non-small cell lung cancer in patients with smoking-related chronic obstructive pulmonary disease

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Abstract

Background

The purpose of this study was to clarify the clinicopathologic characteristics of non-small cell lung cancer (NSCLC) patients with smoking-related chronic obstructive pulmonary disease (COPD) and to evaluate the biological behavior of this disease. We investigated the association between smoking-related COPD, the recurrence-free proportion (RFP) and the clinicopathological features of clinical stage I NSCLC patients.

Methods

Between 2005 and 2014, 218 consecutive patients with clinical stage I NSCLC underwent complete resection with lobectomy or greater and systematic lymph node dissection. Differences in categorical outcomes were evaluated by the χ2 test. RFPs were estimated using the Kaplan–Meier method, and differences were evaluated using the log-rank test.

Results

The 5-year RFP of clinical stage I NSCLC patients with smoking-related COPD was 55%, which was significantly lower than in those without smoking-related COPD (85%; p < 0.001). Postoperative pathological factors, including moderate or poor histological differentiation, intratumoral vascular invasion and lymph node metastasis, were detected more often in patients with smoking-related COPD. In adenocarcinoma patients, the 5-year RFP of patients with smoking-related COPD was 47%, which was significantly lower than in those without smoking-related COPD (87%; p < 0.001). The presence of a solid component was more frequently found in patients with smoking-related COPD (p = 0.007).

Conclusion

Clinical stage I NSCLC patients with smoking-related COPD have histologically more invasive tumors than those without smoking-related COPD.

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Authors and Affiliations

  1. Department of Thoracic and Breast Surgery, Faculty of Medicine, University of Miyazaki, Kihara 5200, Kiyotake, Miyazaki, 889-1692, Japan

    Ryo Maeda & Masaki Tomita

  2. Department of Thoracic Surgery, Kanazawa Medical University, Kanazawa, Japan

    Katsuo Usuda & Hidetaka Uramoto

Authors
  1. Ryo Maeda
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  2. Masaki Tomita
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  3. Katsuo Usuda
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  4. Hidetaka Uramoto
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Correspondence to Ryo Maeda.

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The authors have declared that no conflict of interest exists.

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Maeda, R., Tomita, M., Usuda, K. et al. Clinicopathologic characteristics of non-small cell lung cancer in patients with smoking-related chronic obstructive pulmonary disease. Gen Thorac Cardiovasc Surg 67, 239–246 (2019). https://doi.org/10.1007/s11748-018-1007-x

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  • DOI: https://doi.org/10.1007/s11748-018-1007-x

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