Granulocyte colony stimulating factor-producing lung cancer with severe anemia of inflammation
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Granulocyte colony stimulating factor (G-CSF)-producing lung cancer occasionally induces severe inflammation with an abnormally high white blood cell count. Herein, we report a 49-year-old man who suffered from resectable G-CSF-producing non-small cell lung cancer with continuous fever and severe anemia. Red blood cell transfusion was necessary for the anemia of inflammation. The patient underwent complete surgical tumor resection. The histopathological diagnosis was a pleomorphic carcinoma at pathological stage IIB. This is apparently the first successful case of surgical resection of G-CSF-producing lung cancer in a patient with severe anemia and uncontrollable fever.
KeywordsG-CSF-producing lung cancer Anemia of inflammation IL-6
The authors are indebted to Dr. Edward Barroga (http://orcid.org/0000-0002-8920-2607), Associate Professor and Senior Medical Editor from the Department of International Medical Communications of Tokyo Medical University for editing and reviewing the English manuscript. The authors also thank Hitomi Yokota for her skillful technical assistance.
Compliance with ethical standards
Conflict of interest
The authors declare no conflicts of interest associated with this study.
- 4.Yamamoto M, Manabe S, Moriyama Y, Ishii H, Tanaka S, Takahashi R, et al. Long-term remission achieved via combined chemotherapy and radiotherapy in a non-resectable granulocyte colony-stimulating factor producing pleomorphic carcinoma of the lung. Intern Med. 2013;52(19):2259–63.CrossRefPubMedGoogle Scholar