General Thoracic and Cardiovascular Surgery

, Volume 66, Issue 4, pp 239–242 | Cite as

A case of atypical type A thymoma with vascular invasion and lung metastasis

  • Naoya Kawakita
  • Kazuya Kondo
  • Hiroaki Toba
  • Akiko Yoneda
  • Hiromitsu Takizawa
  • Akira Tangoku
Case Report
  • 141 Downloads

Abstract

We present a case of type A thymoma with invasion of the left brachiocephalic vein and lung metastases. An 84-year-old man underwent extended thymectomy combined with left brachiocephalic vein reconstruction and resection of a lung metastasis. Histological examination showed vascular invasion by the tumor. The lung metastasis had high mitotic activity and slight nuclear enlargement, the so-called “atypical” features, but the main part of the primary tumor did not. However, the intravascular portion of the tumor had “atypical” histological features like the lung metastasis. It seems that “atypical” histological features are related to clinically malignant behavior.

Keywords

Thymoma Thymic carcinoma Pathology Lung metastasis 

Notes

Acknowledgements

No funding was provided for this case report.

Compliance with ethical standards

Conflict of interest

All authors declare no conflict of interest associated with this manuscript.

References

  1. 1.
    Okumura M, Ohta M, Tateyama H, Nakagawa K, Matsumura A, Maeda H, et al. The World Health Organization histologic classification system reflects the oncologic behavior of thymoma: a clinical study of 273 patients. Cancer. 2002;94:624–32.CrossRefPubMedGoogle Scholar
  2. 2.
    Kondo K, Yoshizawa K, Tsuyuguchi M, Kimura S, Sumitomo M, Morita J, et al. Who histologic classification is a prognostic indicator in thymoma. Ann Thorac Surg. 2004;77:1183–8.CrossRefPubMedGoogle Scholar
  3. 3.
    Marx A, Chan JK, Coindre JM, Detterbeck FC, Giard N, Harris NL, et al. The 2015 World Health Organization classification of tumors of the thymus: continuity and changes. J Thorac Oncol. 2015;10:1383–95.CrossRefPubMedPubMedCentralGoogle Scholar
  4. 4.
    Weis CA, Yao X, Deng Y, Detterbeck FC, Marino M, Nicholson AG, et al. The impact of thymoma histotype on prognosis in a worldwide database. J Thorac Oncol. 2015;10:367–72.CrossRefPubMedPubMedCentralGoogle Scholar
  5. 5.
    Vladislav IT, Gokmen-Polar Y, Kesler KA, Loehrer PJ Sr, Badve S. The role of histology in predicting recurrence of type a thymomas: a clinicopathologic correlation of 23 cases. Mod Pathol. 2013;26:1059–64.CrossRefPubMedGoogle Scholar
  6. 6.
    Green AC, Marx A, Strobel P, Marson M, Lim E, Jordan S, et al. Type a and ab thymomas: histological features associated with increased stage. Histopathology. 2015;66:884–91.CrossRefPubMedGoogle Scholar
  7. 7.
    Burger T, Schaefer IM, Kuffer S, Bohnenberger H, Reuter-Jessen K, Chan JK, et al. Metastatic type a thymoma: morphologic and genetic correlation. Histopathology. 2017;70:704–10.CrossRefPubMedGoogle Scholar

Copyright information

© The Japanese Association for Thoracic Surgery 2017

Authors and Affiliations

  • Naoya Kawakita
    • 1
  • Kazuya Kondo
    • 2
  • Hiroaki Toba
    • 1
  • Akiko Yoneda
    • 3
  • Hiromitsu Takizawa
    • 1
  • Akira Tangoku
    • 1
  1. 1.Department of Thoracic and Endocrine Surgery and Oncology, Institute of Health BiosciencesThe University of Tokushima Graduate SchoolTokushimaJapan
  2. 2.Department of Oncological Medical Services, Graduate School of Biomedical BiosciencesTokushima UniversityTokushimaJapan
  3. 3.Department of PathologyTokushima University HospitalTokushimaJapan

Personalised recommendations