Skip to main content

Advertisement

SpringerLink
Log in

A case of atypical type A thymoma with vascular invasion and lung metastasis

  • Case Report
  • Published:
General Thoracic and Cardiovascular Surgery Aims and scope Submit manuscript

Abstract

We present a case of type A thymoma with invasion of the left brachiocephalic vein and lung metastases. An 84-year-old man underwent extended thymectomy combined with left brachiocephalic vein reconstruction and resection of a lung metastasis. Histological examination showed vascular invasion by the tumor. The lung metastasis had high mitotic activity and slight nuclear enlargement, the so-called “atypical” features, but the main part of the primary tumor did not. However, the intravascular portion of the tumor had “atypical” histological features like the lung metastasis. It seems that “atypical” histological features are related to clinically malignant behavior.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Fig. 1
Fig. 2
Fig. 3

Similar content being viewed by others

References

  1. Okumura M, Ohta M, Tateyama H, Nakagawa K, Matsumura A, Maeda H, et al. The World Health Organization histologic classification system reflects the oncologic behavior of thymoma: a clinical study of 273 patients. Cancer. 2002;94:624–32.

    Article  PubMed  Google Scholar 

  2. Kondo K, Yoshizawa K, Tsuyuguchi M, Kimura S, Sumitomo M, Morita J, et al. Who histologic classification is a prognostic indicator in thymoma. Ann Thorac Surg. 2004;77:1183–8.

    Article  PubMed  Google Scholar 

  3. Marx A, Chan JK, Coindre JM, Detterbeck FC, Giard N, Harris NL, et al. The 2015 World Health Organization classification of tumors of the thymus: continuity and changes. J Thorac Oncol. 2015;10:1383–95.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  4. Weis CA, Yao X, Deng Y, Detterbeck FC, Marino M, Nicholson AG, et al. The impact of thymoma histotype on prognosis in a worldwide database. J Thorac Oncol. 2015;10:367–72.

    Article  PubMed  PubMed Central  Google Scholar 

  5. Vladislav IT, Gokmen-Polar Y, Kesler KA, Loehrer PJ Sr, Badve S. The role of histology in predicting recurrence of type a thymomas: a clinicopathologic correlation of 23 cases. Mod Pathol. 2013;26:1059–64.

    Article  PubMed  Google Scholar 

  6. Green AC, Marx A, Strobel P, Marson M, Lim E, Jordan S, et al. Type a and ab thymomas: histological features associated with increased stage. Histopathology. 2015;66:884–91.

    Article  PubMed  Google Scholar 

  7. Burger T, Schaefer IM, Kuffer S, Bohnenberger H, Reuter-Jessen K, Chan JK, et al. Metastatic type a thymoma: morphologic and genetic correlation. Histopathology. 2017;70:704–10.

    Article  PubMed  Google Scholar 

Download references

Acknowledgements

No funding was provided for this case report.

Author information

Authors and Affiliations

  1. Department of Thoracic and Endocrine Surgery and Oncology, Institute of Health Biosciences, The University of Tokushima Graduate School, 3-18-15 Kuramoto-cho, Tokushima, 770-8503, Japan

    Naoya Kawakita, Hiroaki Toba, Hiromitsu Takizawa & Akira Tangoku

  2. Department of Oncological Medical Services, Graduate School of Biomedical Biosciences, Tokushima University, Tokushima, Japan

    Kazuya Kondo

  3. Department of Pathology, Tokushima University Hospital, Tokushima, Japan

    Akiko Yoneda

Authors
  1. Naoya Kawakita
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Kazuya Kondo
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Hiroaki Toba
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Akiko Yoneda
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. Hiromitsu Takizawa
    View author publications

    You can also search for this author in PubMed Google Scholar

  6. Akira Tangoku
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Naoya Kawakita.

Ethics declarations

Conflict of interest

All authors declare no conflict of interest associated with this manuscript.

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Kawakita, N., Kondo, K., Toba, H. et al. A case of atypical type A thymoma with vascular invasion and lung metastasis. Gen Thorac Cardiovasc Surg 66, 239–242 (2018). https://doi.org/10.1007/s11748-017-0794-9

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s11748-017-0794-9

Keywords

Search

Navigation