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Insights into the Dissolution Kinetics of NaLAS Tablets

  • Original Article
  • Published:
Journal of Surfactants and Detergents

Abstract

In this work, the dissolution behaviors of a series of sodium alkylbenzenesulfonates (NaLAS) tablets with different moisture contents and neutralization degrees were investigated in aqueous solution. The ANOVA-based, model-independent and model-dependent methods were employed to perform comparison analyses on dissolution profiles. The measurements of powder X-ray diffraction patterns and mechanical properties elucidate distinct differences in each formula. The results show that ANOVA provides a possibility for finding the source of differences among different variables, and the model-independent methods including the k values and mean dissolution time are easy to interpret and perform comparison analyses. The Hixson–Crowell model gives satisfactory correlation results for the dissolution data and the dissolution kinetics parameters are obtained. The inhibition effects of neutralization degree and moisture content on NaLAS dissolution were examined, which reveals that the increase in lamellar phase proportion leads to the reduction of dissolution rate. The comparison analyses performed in this work form part of a methodology for dissolution profile prediction and comparison.

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References

  1. Miller CA. Dissolution rates of surfactants. Adv Polym Sci. 2008;218:3–24.

    Article  CAS  Google Scholar 

  2. Oliver-Rodríguez B, Zafra-Gómez A, Reis MS, Duarte BPM, Verge C, de Ferrer JA, Pérez-Pascual M, Vílchez JL. Evaluation of linear alkylbenzene sulfonate (LAS) behaviour in agricultural soil through laboratory continuous studies. Chemosphere. 2015;131:1–8.

    Article  Google Scholar 

  3. Holmberg K, Bo J, Kronberg B, Lindman B. Surfactants and polymers in aqueous solution. 2nd ed. Chichester: Wiley; 2003.

    Google Scholar 

  4. Scheibel JJ. The evolution of anionic surfactant technology to meet the requirements of the laundry detergent industry. J Surfactants Deterg. 2004;7(4):319–28.

    Article  CAS  Google Scholar 

  5. Yu Y, Zhao J, Bayly AE. Development of surfactants and builders in detergent formulations. Chin J Chem Eng. 2008;16(4):517–27.

    Article  CAS  Google Scholar 

  6. Sanderson H, Dyer SD, Price BB, Nielsen AM, van Compernolle R, Selby M, Stanton K, Evans A, Ciarlo M, Sedlak R. Occurrence and weight-of-evidence risk assessment of alkyl sulfates, alkyl ethoxysulfates, and linear alkylbenzene sulfonates (LAS) in river water and sediments. Sci Total Environ. 2006;368(2):695–712.

    Article  CAS  Google Scholar 

  7. Appel PW. Modern methods of detergent manufacture. J Surfactants Deterg. 2000;3(3):395–405.

    Article  CAS  Google Scholar 

  8. Walsh JM, Tiddy GJT. Liquid crystal phase behavior of branched poly(oxyethylene) surfactants. Langmuir. 2003;19(14):5586–94.

    Article  CAS  Google Scholar 

  9. Stewart JA, Saiani A, Bayly A, Tiddy GJT. The phase behaviour of lyotropic liquid crystals in linear alkylbenzene sulphonate (LAS) systems. Colloids Surf A. 2009;338(1):155–61.

    Article  CAS  Google Scholar 

  10. Richards C, Tiddy GJT, Casey S. Lateral phase separation gives multiple lamellar phases in a “binary” surfactant/water system: the phase behavior of sodium alkyl benzene sulfonate/water mixtures. Langmuir. 2007;23(2):467–74.

    Article  CAS  Google Scholar 

  11. Ramaraju SM, Carroll BJ, Chambers JG, Tiddy GJT. The liquid crystalline phases formed by linear-dodecylbenzene sulphonic acid during neutralisation with sodium carbonate. Colloids Surf A. 2006;288(1–3):77–85.

    Article  CAS  Google Scholar 

  12. Stewart JA, Saiani A, Bayly A, Tiddy GJT. Phase behavior of lyotropic liquid crystals in linear alkylbenzene sulphonate (LAS) systems in the presence of dilute and concentrated electrolyte. J Disper Sci Technol. 2011;32(12):1700–10.

    Article  CAS  Google Scholar 

  13. Richards C, Tiddy GJT, Casey S. Liquid crystal and solution phases of sodium dodecyl-p-benzene sulphonate (NaLAS) and octa-oxyethylene glycol hexadecyl ether (C16E8): 1:1 mixtures in water. Colloid Polym Sci. 2008;286(1):31–46.

    Article  CAS  Google Scholar 

  14. Dokoumetzidis A, Macheras P. A century of dissolution research: from Noyes and Whitney to the biopharmaceutics classification system. Int J Pharm. 2006;321(1):1–11.

    Article  CAS  Google Scholar 

  15. Ahuja N, Katare OP, Singh B. Studies on dissolution enhancement and mathematical modeling of drug release of a poorly water-soluble drug using water-soluble carriers. Eur J Pharm Biopharm. 2007;65(1):26–38.

    Article  CAS  Google Scholar 

  16. Heng D, Cutler DJ, Chan HK, Yun J, Raper JA. Dissolution kinetic behavior of drug nanoparticles and their conformity to the diffusion model. Langmuir. 2008;24(14):7538–44.

    Article  CAS  Google Scholar 

  17. Yuksel N, Kanık AE, Baykara T. Comparison of in vitro dissolution profiles by ANOVA-based, model-dependent and-independent methods. Int J Pharm. 2000;209(1):57–67.

    Article  CAS  Google Scholar 

  18. Anderson N, Bauer M, Boussac N, Khan-Malek R, Munden P, Sardaro M. An evaluation of fit factors and dissolution efficiency for the comparison of in vitro dissolution profiles. J Pharm Biomed Anal. 1998;17(4):811–22.

    Article  CAS  Google Scholar 

  19. Polli JE, Rekhi GS, Augsburger LL, Shah VP. Methods to compare dissolution profiles and a rationale for wide dissolution specifications for metoprolol tartrate tablets. J Pharm Sci. 1997;86(6):690–700.

    Article  CAS  Google Scholar 

  20. Costa P, Lobo JMS. Modeling and comparison of dissolution profiles. Eur J Pharm Sci. 2001;13(2):123–33.

    Article  CAS  Google Scholar 

  21. Hixson AW, Crowell JH. Dependence of reaction velocity upon surface and agitation. Ind Eng Chem. 1931;23(10):1160–8.

    Article  CAS  Google Scholar 

  22. Rinaki E, Dokoumetzidis A, Macheras P. The mean dissolution time depends on the dose/solubility ratio. Pharm Res. 2003;20(3):406–8.

    Article  CAS  Google Scholar 

  23. Noyes AA, Whitney WR. The rate of solution of solid substances in their own solutions. J Am Chem Soc. 1897;19(12):930–4.

    Article  Google Scholar 

  24. Dokoumetzidis A, Papadopoulou V, Macheras P. Analysis of dissolution data using modified versions of Noyes–Whitney equation and the Weibull function. Pharm Res. 2006;23(2):256–61.

    CAS  Google Scholar 

  25. Fagerberg JH, Tsinman O, Sun N, Tsinman K, Avdeef A, Bergström CAS. Dissolution rate and apparent solubility of poorly soluble drugs in biorelevant dissolution media. Mol Pharm. 2010;7(5):1419–30.

    Article  CAS  Google Scholar 

  26. Polli JE, Rekhi GS, Shah VP. Methods to compare dissolution profiles. Drug Inf J. 1996;30(4):1113–20.

    Article  Google Scholar 

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Acknowledgements

P&G Technology (Beijing) Co., Ltd. is gratefully acknowledged for kindly providing experimental facilities and financial support.

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Authors and Affiliations

  1. School of Chemical Engineering and Technology, Tianjin University, Tianjin, 300072, People’s Republic of China

    Bochen Pan, Jiapeng Li, Jun Jiang, Yao Tong, Leping Dang & Hongyuan Wei

  2. Procter & Gamble Technology (Beijing) Co., Ltd., Shunyi District, Beijing, 101312, People’s Republic of China

    Rui Shen & Zhe Guan

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  1. Bochen Pan
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  2. Rui Shen
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  3. Zhe Guan
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  4. Jiapeng Li
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  5. Jun Jiang
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Correspondence to Leping Dang.

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Pan, B., Shen, R., Guan, Z. et al. Insights into the Dissolution Kinetics of NaLAS Tablets. J Surfact Deterg 20, 1433–1441 (2017). https://doi.org/10.1007/s11743-017-2017-x

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