Septic arthritis in the antimicrobial stewardship era

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  1. 1.

    Ben-Chetrit E, Zamir A, Natsheh A, Nesher G, Wiener-Well Y, Breuer GS. Trends in antimicrobial resistance among bacteria causing septic arthritis in adults in a single center: A 15-years retrospective analysis. Intern Emerg Med. 2019 Nov 29.

  2. 2.

    Mathews CJ, Weston VC, Jones A, Field M, Coakley G (2010) Bacterial septic arthritis in adults. Lancet 375(9717):846–855

    Article  Google Scholar 

  3. 3.

    Nair R, Schweizer ML, Singh N (2017) Septic Arthritis and Prosthetic Joint Infections in Older Adults. Infect Dis Clin North Am 31(4):715–729

    Article  Google Scholar 

  4. 4.

    Grammatico-Guillon L, Baron S, Gettner S, Lecuyer AI, Gaborit C, Rosset P, Rusch E, Bernard L (2012) Bone and joint infections in hospitalized patients in France, 2008: clinical and economic outcomes. J Hosp Infect 82(1):40–48

    CAS  Article  Google Scholar 

  5. 5.

    Spellberg B (2016) The New Antibiotic Mantra-"Shorter Is Better". JAMA Intern Med 176(9):1254–1255

    Article  Google Scholar 

  6. 6.

    Gjika E, Beaulieu JY, Vakalopoulos K, Gauthier M, Bouvet C, Gonzalez A, Morello V, Steiger C, Hirsiger S, Lipsky BA, Uçkay I (2019) Two weeks versus four weeks of antibiotic therapy after surgical drainage for native joint bacterial arthritis: a prospective, randomised, non-inferiority trial. Ann Rheum Dis 78(8):1114–1121

    CAS  Article  Google Scholar 

  7. 7.

    Uçkay I, Tovmirzaeva L, Garbino J, Rohner P, Tahintzi P, Suvà D, Assal M, Hoffmeyer P, Bernard L, Lew D (2013) Short parenteral antibiotic treatment for adult septic arthritis after successful drainage. Int J Infect Dis 17(3):e199–205

    Article  Google Scholar 

  8. 8.

    Li HK, Rombach I, Zambellas R, Walker AS, McNally MA, Atkins BL, Lipsky BA, Hughes HC, Bose D, Kümin M, Scarborough C, Matthews PC, Brent AJ, Lomas J, Gundle R, Rogers M, Taylor A, Angus B, Byren I, Berendt AR, Warren S, Fitzgerald FE, Mack DJF, Hopkins S, Folb J, Reynolds HE, Moore E, Marshall J, Jenkins N, Moran CE, Woodhouse AF, Stafford S, Seaton RA, Vallance C, Hemsley CJ, Bisnauthsing K, Sandoe JAT, Aggarwal I, Ellis SC, Bunn DJ, Sutherland RK, Barlow G, Cooper C,Geue C, McMeekin N, Briggs AH, Sendi P, Khatamzas E, Wangrangsimakul T, Wong THN,Barrett LK, Alvand A, Old CF, Bostock J, Paul J, Cooke G, Thwaites GE, Bejon P,Scarborough M; OVIVA Trial Collaborators. Oral versus Intravenous Antibiotics for Bone and Joint Infection. N Engl J Med. 2019;380(5):425–436.

  9. 9.

    Bassetti M, Eckmann C, Peghin M, Carnelutti A, Righi E (2018) When to switch to an oral treatment and/or to discharge a patient with skin and soft tissue infections. Curr Opin Infect Dis 31(2):163–169

    Article  Google Scholar 

  10. 10.

    Chapman ALN, Patel S, Horner C, Gilchrist M, Seaton RA (2019) Outpatient parenteral antimicrobial therapy: updated recommendations from the UK. J Antimicrob Chemother 74(11):3125–3127

    CAS  Article  Google Scholar 

  11. 11.

    Bryant PA, Katz NT (2018) Inpatient versus outpatient parenteral antibiotic therapy at home for acute infections in children: a systematic review. Lancet Infect Dis 18(2):e45–e54

    Article  Google Scholar 

  12. 12.

    Agarwal R, Bartsch SM, Kelly BJ, Prewitt M, Liu Y, Chen Y, Umscheid CA (2018) Newer glycopeptide antibiotics for treatment of complicated skin and soft tissue infections: systematic review, network meta-analysis and cost analysis. Clin Microbiol Infect 24(4):361–368

    CAS  Article  Google Scholar 

  13. 13.

    Rappo U, Puttagunta S, Shevchenko V, Shevchenko A, Jandourek A, Gonzalez PL,Suen A, Mas Casullo V, Melnick D, Miceli R, Kovacevic M, De Bock G, Dunne MW. Dalbavancin for the Treatment of Osteomyelitis in Adult Patients: A Randomized Clinical Trial of Efficacy and Safety. Open Forum Infect Dis. 2018;6(1):ofy331.

  14. 14.

    Hassan AS, Rao A, Manadan AM, Block JA (2017) Peripheral Bacterial Septic Arthritis: Review of Diagnosis and Management. J Clin Rheumatol 23(8):435–442

    Article  Google Scholar 

  15. 15.

    Cassini A, Högberg LD, Plachouras D, Quattrocchi A, Hoxha A, Simonsen GS, Colomb-Cotinat M, Kretzschmar ME, Devleesschauwer B, Cecchini M, Ouakrim DA, Oliveira TC, Struelens MJ, Suetens C, Monnet DL; Burden of AMR Collaborative Group. Attributable deaths and disability-adjusted life-years caused by infections with antibiotic-resistant bacteria in the EU and the European Economic Area in 2015: a population-level modelling analysis. Lancet Infect Dis. 2019;19(1):56–66.

  16. 16.

    Chatterjee SS, Otto M (2013) Improved understanding of factors driving methicillin-resistant Staphylococcus aureus epidemic waves. Clin Epidemiol 5:205–217

    Google Scholar 

  17. 17.

    Diekema DJ, Pfaller MA, Shortridge D, Zervos M, Jones RN (2019) Twenty-Year Trends in Antimicrobial Susceptibilities Among Staphylococcus aureus From the SENTRY Antimicrobial Surveillance Program. Open Forum Infect Dis 6(Suppl 1):S47–S53

    Article  Google Scholar 

  18. 18.

    Chambers HF, Deleo FR (2009) Waves of resistance: Staphylococcus aureus in the antibiotic era. Nat Rev Microbiol 7(9):629–641

    CAS  Article  Google Scholar 

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Correspondence to Michele Spinicci.

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Spinicci, M., Corti, G. Septic arthritis in the antimicrobial stewardship era. Intern Emerg Med 15, 567–569 (2020).

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