Internal and Emergency Medicine

, Volume 14, Issue 1, pp 17–19 | Cite as

Daylight saving time and circadian rhythms in the neuro-endocrine-immune system: impact on cardiovascular health

  • Roberto TarquiniEmail author
  • Annalucia Carbone
  • Micaela Martinez
  • Gianluigi MazzoccoliEmail author

The proper functioning of the physiological processes in living beings is regulated by numerous naturally occurring daily rhythms that have evolved to anticipate and prepare for environmental changes due to the solar day and year, allowing organisms to predict when environmental challenges are most likely to occur [1].

The recurrence of biological processes cycling at different frequency ranges enables healthy organisms to maintain homeostasis, that is the body’s ability to regulate stability in its inner environment in response to changing conditions in the outside environment. Rhythmic processes hallmarked by the same frequency may have the same phase or different phases, and usually show well-defined time-relationships to each other: functional disturbances and alteration of anatomic integrity may be caused by loss of this multi-frequency time structure leading to internal desynchronization [2].

Previous results show a transient change in timing and incidence of acute myocardial...



The work in GM’s laboratory was supported by the “5 × 1000” voluntary contribution, and by a Grant from the Italian Ministry of Health through Department of Medical Sciences, Division of Internal Medicine and Laboratory of Chronobiology (RC1803ME40), Fondazione IRCCS “Casa Sollievo della Sofferenza”, Opera di Padre Pio da Pietrelcina, San Giovanni Rotondo (FG), Italy.

Compliance with ethical standards

Conflict of interest

The authors declare that they have no conflict of interest.

Research involving in human and animal rights

This article does not contain any studies with animals performed by any of the authors. Subjects in the study participated willingly.

Informed consent

Human participants gave written informed consent.


  1. 1.
    Aschoff J (ed) (1981) Biological rhythms. Handbook of behavioural neurobiology, vol 4. Plenum Publishing Corporation, New York, p 4Google Scholar
  2. 2.
    Vinciguerra M, Tevy MF, Mazzoccoli G (2014) A ticking clock links metabolic pathways and organ systems function in health and disease. Clin Exp Med 14(2):133–140CrossRefPubMedGoogle Scholar
  3. 3.
    Janszky I, Ljung R (2008) Shifts to and from daylight savings time and incidence of myocardial infarction. N Engl J Med 359:1966–1968CrossRefPubMedGoogle Scholar
  4. 4.
    Jiddou MR, Pica M, Boura J, Qu L, Franklin BA (2013) Incidence of myocardial infarction with shifts to and from daylight savings time. Am J Cardiol 111:631–635CrossRefPubMedGoogle Scholar
  5. 5.
    Sipilä JO, Rautava P, Kytö V (2016) Association of daylight saving time transitions with incidence and in-hospital mortality of myocardial infarction in Finland. Ann Med 48(1–2):10–16CrossRefPubMedGoogle Scholar
  6. 6.
    Manfredini R, Fabbian F, Cappadona R, Modesti PA (2018) Daylight saving time, circadian rhythms, and cardiovascular health. Intern Emerg Med 13(5):641–646CrossRefPubMedPubMedCentralGoogle Scholar
  7. 7.
    Mazzoccoli G (2011) The timing clockwork of life. J Biol Regul Homeost Agents 25(1):137–143PubMedGoogle Scholar
  8. 8.
    Mazzoccoli G, De Cata A, Greco A, Carughi S, Giuliani F, Tarquini R (2010) Circadian rhythmicity of lymphocyte subpopulations and relationship with neuro-endocrine system. J Biol Regul Homeost Agents 24(3):341–350PubMedGoogle Scholar
  9. 9.
    Tarquini R, Clock Mazzoccoli G, Genes Metabolism, Risk Cardiovascular (2017) Clock genes, metabolism, and cardiovascular risk. Heart Fail Clin 13(4):645–655CrossRefPubMedGoogle Scholar
  10. 10.
    Mazzoccoli G, De Cosmo S, Mazza T (2018) The biological clock: a pivotal hub in non-alcoholic fatty liver disease pathogenesis. Front Physiol 15(9):193CrossRefGoogle Scholar

Copyright information

© Società Italiana di Medicina Interna 2018

Authors and Affiliations

  1. 1.Department of Clinical and Experimental Medicine, School of MedicineUniversity of FlorenceFlorenceItaly
  2. 2.Inter-institutional Department for Continuity of Care of Empoli, School of MedicineUniversity of FlorenceFlorenceItaly
  3. 3.Division of Internal Medicine and Laboratory of Chronobiology, Department of Medical SciencesFondazione IRCCS “Casa Sollievo Della Sofferenza”FoggiaItaly
  4. 4.Department of Environmental Health Sciences, Mailman School of Public HealthColumbia UniversityNew YorkUSA

Personalised recommendations