Internal and Emergency Medicine

, Volume 14, Issue 1, pp 1–3 | Cite as

Silybin and metabolic disorders

  • Pasquale PignatelliEmail author
  • Roberto Carnevale
  • Danilo Menichelli
Mediterranean diet represents a fundamental strategy in the prevention of cardiovascular and metabolic disorders as demonstrated by observational and interventional trials [ 1]. Among the most represented elements of the Mediterranean diet are polyphenols that display protective effects on cardiometabolic disorders by counteracting oxidative stress that represent a key point of the preventive strategy in this setting. Hence, oxidative stress seems to be involved in both cardiovascular and metabolic disorders [ 2]. Indeed, atherosclerotic disease is associated with increased level of oxidative stress [ 3] as well as metabolic disorders such as non-alcoholic fatty liver disease (NAFLD) [ 4] and diabetes [ 5] (Fig.  1).


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The authors declare that they have no conflict of interest.

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© Società Italiana di Medicina Interna 2018

Authors and Affiliations

  • Pasquale Pignatelli
    • 1
    Email author
  • Roberto Carnevale
    • 2
  • Danilo Menichelli
    • 1
  1. 1.Department of Internal Medicine and Medical Specialties, I Clinica MedicaAtherothrombosis Centre, Sapienza University of RomeRomeItaly
  2. 2.Department of Medical-Surgical Sciences and BiotechnologiesSapienza University of RomeLatinaItaly

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