In-hospital mortality for toxic megacolon
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Toxic megacolon (TM) is a life-threatening condition that develops when severe colonic inflammation originating from any kind of mucosal injury (immune-mediated, infective, ischaemic, neoplastic, iatrogenic) causes muscular atony and systemic toxicity . Despite its reduced prevalence, the outcome is still unsatisfactory, and a substantial number of patients undergo colectomy. In this context, the paper by Doshi and coworkers , reporting the results of the analysis of the data collected in the Nationwide Inpatient Sample database from January 2010 through December 2014, is of interest and offers some food for thought. Obviously, it has some intrinsic weaknesses related to the retrospective design of the study, the absence of a control group, and the overestimation of the prevalence of TM due to the lack of differentiation between first admission and subsequent re-admission of the same patient. Nonetheless, the identification of those factors associated with a poor outcome...
Inflammatory bowel diseases
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Conflict of interest
The authors have no potential conflicts of interest to declare.
Statement of human and animal rights
The work was carried out in agreement with the Declaration of Helsinki.
No informed consent was necessary for the study.
- 6.Loo VG, Poirier L, Miller MA, Oughton M, Libman MD, Michaud S, Bourgault AM, Nguyen T, Frenette C, Kelly M, Vibien A, Brassard P, Fenn S, Dewar K, Hudson TJ, Horn R, René P, Monczak Y, Dascal A (2005) A predominantly clonal multi-institutional outbreak of Clostridium difficile-associated diarrhea with high morbidity and mortality. N Engl J Med 353:2442–2449. https://doi.org/10.1056/nejmoa051639 CrossRefPubMedGoogle Scholar
- 9.Shen NT, Maw A, Tmanova LL, Pino A, Ancy K, Crawford CV, Simon MS, Evans AT (2017) Timely use of probiotics in hospitalized adults prevents Clostridium difficile infection: a systematic review with meta-regression analysis. Gastroenterology 152:1889–1900. https://doi.org/10.1053/j.gastro.2017.02.003 CrossRefPubMedGoogle Scholar