Internal and Emergency Medicine

, Volume 13, Issue 6, pp 837–838 | Cite as

In-hospital mortality for toxic megacolon

  • Rachele CiccocioppoEmail author
  • Gino Roberto Corazza

Toxic megacolon (TM) is a life-threatening condition that develops when severe colonic inflammation originating from any kind of mucosal injury (immune-mediated, infective, ischaemic, neoplastic, iatrogenic) causes muscular atony and systemic toxicity [1]. Despite its reduced prevalence, the outcome is still unsatisfactory, and a substantial number of patients undergo colectomy. In this context, the paper by Doshi and coworkers [2], reporting the results of the analysis of the data collected in the Nationwide Inpatient Sample database from January 2010 through December 2014, is of interest and offers some food for thought. Obviously, it has some intrinsic weaknesses related to the retrospective design of the study, the absence of a control group, and the overestimation of the prevalence of TM due to the lack of differentiation between first admission and subsequent re-admission of the same patient. Nonetheless, the identification of those factors associated with a poor outcome...



Clostridium difficile


Inflammatory bowel diseases


Toxic megacolon


Compliance with ethical standards

Conflict of interest

The authors have no potential conflicts of interest to declare.

Statement of human and animal rights

The work was carried out in agreement with the Declaration of Helsinki.

Informed consent

No informed consent was necessary for the study.


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Copyright information

© Società Italiana di Medicina Interna 2018

Authors and Affiliations

  1. 1.Gastroenterology Unit, Department of Medicine, AOUI Policlinico G.B. RossiUniversity of VeronaVeronaItaly
  2. 2.Clinica Medica I, Department of Internal Medicine, IRCCS San Matteo Hospital FoundationUniversity of PaviaPaviaItaly

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