Internal and Emergency Medicine

, Volume 13, Issue 3, pp 429–431 | Cite as

A simplified diagnostic algorithm for the management of suspected pulmonary embolism: the YEARS study

  • Marco ManzoniEmail author
  • Matteo Reggiani
  • on behalf of GrAM (Gruppo di Autoformazione Metodologica)


The significant clinical burden of venous thromboembolism (VTE) is expressed by its high rate of mortality and morbidity: sudden death is the clinical presentation in almost 25% of patients with pulmonary embolism (PE), and about 15% of patients with a PE dies within 3 months, about half of them because of the direct consequences of the PE. The estimated annual incidence rates of overall VTE range from 104 to 183 per 100,000 person-years in Europe, with the higher rate observed in older people [1]. The clinical picture of PE is non-specific: consequently, when PE is suspected, a computed tomography pulmonary angiography (CTPA) is generally performed to confirm or exclude the diagnosis, owing to its high diagnostic accuracy. However, considering the risk of radiation exposure, of contrast-induced nephropathy and the elevated costs, the number of performed CTPA should be restricted. Therefore, diagnostic algorithms have been introduced and validated, with the aim of safely...


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Conflict of interest

The authors declare that they have no conflict of interest.

Statement of human and animal rights

All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional and/or national research committee and with the 1964 Helsinki declaration and its later amendments or comparable ethical standards. This article does not contain any studies with human and animals performed by any of the authors.

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© SIMI 2018

Authors and Affiliations

  1. 1.Unità di Medicina III, ASST Santi Paolo e Carlo, Dipartimento di Scienze della SaluteUniversità degli Studi di MilanoMilanItaly

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