Internal and Emergency Medicine

, Volume 13, Issue 3, pp 321–323 | Cite as

Pancreatic cancer: risk and preventive factors

  • Anna LicataEmail author
  • Giuseppe Montalto
  • Maurizio Soresi

In Asian countries, the increasing incidence of obesity has only recently opened a debate that has been ongoing in the West for a long time, not only regarding its cardiovascular consequences, but also the relationship between obesity, non-alcoholic fatty liver disease (NAFLD), and cancer [1, 2].

In this context, the paper by Chang and colleagues examines the relationship between pancreatic cancer and NAFLD in a Chinese population, a topic on which there have been few studies, so far [3]. These authors retrospectively analyzed 143 patients with pancreatic cancer vs 414 without cancer. They conclude that NAFLD and type 2 diabetes are risk factors independently associated with pancreatic cancer, and that the use of statins and aspirin is a protective factor against neoplasia. Despite the limits of a retrospective study, their paper leads to important considerations.

The association between obesity (in particular the visceral type), NAFLD, and tumors is well known [4, 5]. However, Chang...


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Conflict of interest

The authors declare that they have no conflict of interest.

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This article not contain any studies with human participants or animals perfomed by any of the authors.

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  1. 1.
    Koh JC, Loo WM, Goh KL et al (2016) Asian consensus on the relationship between obesity and gastrointestinal and liver diseases. J Gastroenterol Hepatol 31(8):1405–1413. CrossRefPubMedGoogle Scholar
  2. 2.
    Miele L, Gasbarrini G, Giorgio V, Gasbarrini A, Grieco A (2016) Nonalcoholic fatty liver disease as trigger of cardiovascular and metabolic complication in metabolic syndrome. Intern Emerg Med 11(1):3–10CrossRefPubMedGoogle Scholar
  3. 3.
    Chang CF, Tseng YC, Huang HH, Shih YL, Hsieh TY, Lin HH (2017) Exploring the relationship between non-alcoholic fatty liver disease and pancreatic cancer by computed tomographic survey. Intern Emerg Med. Google Scholar
  4. 4.
    Włodarek D, Jerzy Podleśny JS (2007) Nonalcoholic fatty liver disease as a feature of the metabolic syndrome. Roczniki Państwowego Zakładu 58(1):129Google Scholar
  5. 5.
    Rosato V, Tavani A, Bosetti C, Pelucchi C, Talamini R, Polesel J et al (2011) Metabolic syndrome and pancreatic cancer risk: a case-control study in Italy and meta-analysis. Metabolism 60:1372–1378. CrossRefPubMedGoogle Scholar
  6. 6.
    Soresi M, Noto D, Cefalù AB, Martini S, Vigna GB, Fonda M, Metabolic Syndrome Study Group et al (2013) Non-alcoholic fatty liver and metabolic syndrome in Italy: results from a multicentric study of the Italian Arteriosclerosis society. Acta Diabetol 50(2):241–249. CrossRefPubMedGoogle Scholar
  7. 7.
    Smits MM, van Geenen EJ (2011) The clinical significance of pancreatic steatosis. Nat Rev Gastroenterol Hepatol 8(3):169–177. CrossRefPubMedGoogle Scholar
  8. 8.
    Pacifico L, Di Martino M, Anania C, Andreoli GM, Bezzi M, Catalano C et al (2015) Pancreatic fat and β-cell function in overweight/obese children with nonalcoholic fatty liver disease. World J Gastroenterol 21(15):4688–4695. CrossRefPubMedPubMedCentralGoogle Scholar
  9. 9.
    Després JP (2006) Lemieux I abdominal obesity and metabolic syndrome. Nature 444:881–887CrossRefPubMedGoogle Scholar
  10. 10.
    Della Corte C, Mosca A, Majo F, Lucidi V, Panera N, Giglioni E et al (2015) Nonalcoholic fatty pancreas disease and nonalcoholic fatty liver disease: more than ectopic fat. Clin Endocrinol (Oxf) 83(5):656–662. CrossRefGoogle Scholar
  11. 11.
    Soresi M, Giannitrapani L, Florena AM, La Spada E, Di Gesaro V, Rappa F et al (2009) Reliability of the bright liver echo pattern in diagnosing steatosis in patients with cryptogenic and HCV-related hypertransaminasaemia. Clin Radiol 64:1181–1187CrossRefPubMedGoogle Scholar
  12. 12.
    Gullo L, Salizzoni E, Serra C, Calculli L, Bastagli L, Migliori M (2006) Can pancreatic steatosis explain the finding of pancreatic hyperenzymemia in subjects with dyslipidemia? Pancreas 33(4):351–353CrossRefPubMedGoogle Scholar
  13. 13.
    Vrieling A, Bueno-de-Mesquita HB, Boshuizen HC et al (2010) Cigarette smoking, environmental tobacco smoke exposure and pancreatic cancer risk in the European prospective investigation into cancer and nutrition. Int J Cancer 126(10):2394–2403. PubMedGoogle Scholar
  14. 14.
    Cui X, Xie Y, Chen M, Li J, Liao X, Shen J et al (2012) Statin use and risk of pancreatic cancer: a meta-analysis. Cancer Causes Control 23(7):1099–1111. CrossRefPubMedGoogle Scholar
  15. 15.
    Khurana V, Sheth A, Caldito G, Barkin JS (2007) Statins reduce the risk of pancreatic cancer in humans: a case-control study of half a million veterans. Pancreas 34:260–265CrossRefPubMedGoogle Scholar
  16. 16.
    Walker EJ, Ko AH, Holly EA, Bracci PM (2015) Statin use and risk of pancreatic cancer: results from a large, clinic-based case-control study. Cancer 121:1287–1294CrossRefPubMedPubMedCentralGoogle Scholar
  17. 17.
    Archibugi L, Piciucchi M, Stigliano S, Valente R, Zerboni G, Barucca V et al (2017) Exclusive and combined use of statins and aspirin and the risk of pancreatic cancer: a case-control study. Sci Rep 7(1):13024. CrossRefPubMedPubMedCentralGoogle Scholar
  18. 18.
    Jiang MJ, Dai JJ, Gu DN, Huang Q, Tian L (2016) Aspirin in pancreatic cancer: chemopreventive effects and therapeutic potentials. Biochim Biophys Acta 1866(2):163–176. PubMedGoogle Scholar
  19. 19.
    Zhang YP, Wan YD, Sun YL, Li J, Zhu RT (2015) Aspirin might reduce the incidence of pancreatic cancer: a meta-analysis of observational studies. Sci Rep 5:15460. CrossRefPubMedPubMedCentralGoogle Scholar
  20. 20.
    Polimeni L, Pastori D, Baratta F, Tozzi G, Novo M, Vicinanza R et al (2017) Spleen dimensions are inversely associated with lysosomal acid lipase activity in patients with non-alcoholic fatty liver disease. Intern Emerg Med 12(8):1159–1165CrossRefPubMedGoogle Scholar

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© SIMI 2018

Authors and Affiliations

  • Anna Licata
    • 1
    Email author
  • Giuseppe Montalto
    • 1
  • Maurizio Soresi
    • 1
  1. 1.Internal Medicine & Hepatology, DIBIMISUniversity of PalermoPalermoItaly

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