Internal and Emergency Medicine

, Volume 12, Issue 5, pp 561–563 | Cite as

Is it reasonable to use a lower DOACs dose in some patients with VTE? Yes

  • Davide Imberti
  • Daniela MastroiacovoEmail author


In the Hokusai-VTE trial, 733 patients were treated with the reduced dose edoxaban regimen, which maintained efficacy and safety compared with the 60 mg dose, and was safer than warfarin. The prophylactic doses of apixaban and rivaroxaban reduced the risk of recurrent venous thromboembolism (VTE) in the extended treatment trials. Dabigatran 110 mg was approved by the European Medicine Agency for VTE treatment. Further data from registries and real-world studies will help to clarify whether patients, with other specific characteristics, can benefit from the reduced dose of direct oral anticoagulants.


Venous thromboembolism Direct oral anticoagulants (DOACs) Lower dose 


Compliance with ethical standards

Conflict of interest

The authors declare that they have no competing interests.

Statement of human and animal rights

This article does not contain any studies with human participants or animals performed by any of the authors.

Informed consent

For this type of study formal informed consent is not required.


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Copyright information

© SIMI 2017

Authors and Affiliations

  1. 1.Internal Medicine Department, Piacenza HospitalHaemostasis and Thrombosis CenterPiacenzaItaly
  2. 2.Angiology UnitSS Filippo and Nicola HospitalAvezzanoItaly

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