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Every cloud has a silver lining

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References

  1. Drees M, Pineles L, Harris AD, Morgan DJ (2014) Variation in definitions and isolation procedures for multidrug-resistant Gram-negative bacteria: a survey of the Society for Healthcare Epidemiology of America Research Network. Infect Control Hosp Epidemiol 35(4):362–366. doi:10.1086/675600

    Article  PubMed  Google Scholar 

  2. Magiorakos AP, Srinivasan A, Carey RB, Carmeli Y, Falagas ME et al (2011) Multidrug-resistant, extensively drug-resistant and pandrug-resistant bacteria: an international expert proposal for interim standard definitions for acquired resistance. Clin Microbiol Infect 18:268–281. doi:10.1111/j.1469-0691.2011.03570.x

    Article  PubMed  Google Scholar 

  3. Struve C, Roe CC, Stegger M et al; mBio (2015) Mapping the evolution of hypervirulent K. pneumoniae. Am Soc Microbiol6(4):1–12. doi:10.1128/mBio.00630-15

  4. Podschun R, Ullmann U (1998) Klebsiella spp. as nosocomial pathogens: epidemiology, taxonomy, typing methods, and pathogenicity factors. Clin Microbiol Rev 11(4):589–603

    CAS  PubMed  PubMed Central  Google Scholar 

  5. Falcone M, Russo A, Iacovelli A, Restuccia G, Ceccarelli G, Giordano A, Farcomeni A, Morelli A, Venditti M (2016) Predictors of outcome in ICU patients with septic shock caused by Klebsiella pneumoniae carbapenemase-producing K. pneumoniae. Clin Microbiol Infect 22(5):444–450. doi:10.1016/j.cmi.2016.01.016

    Article  CAS  PubMed  Google Scholar 

  6. Seibert G, Horner R, Meneghetti BH et al (2014) Nosocomial infections by K. pneumoniae carbapenemase producing enterobacteria in a teaching hospital. Einstein (Sao Paulo) 12(3):281–286. doi:10.1590/S1679-45082014AO3131

  7. Satlin MJ, Jenkins SG, Walsh TJ (2014) The global challenge of carbapenem-resistant enterobacteriaceae in transplant recipients and patients with hematologic malignancies. Clin Infect Dis 9(12):1–12. doi:10.1093/cid/ciu052

    Google Scholar 

  8. Lin JN, Chen YH, Chang LL, Lai CH, Lin HL, Lin HH (2011) Clinical characteristics and outcomes of patients with extended-spectrum β-lactamase-producing bacteremias in the emergency department. Intern Emerg Med 6(6):547–555. doi:10.1007/s11739-011-0707-3

    Article  PubMed  Google Scholar 

  9. European Surveillance of Antimicrobial Consumption Network (2014) Antimicrobial resistance interactive database. http://ecdc.europa.eu/en/chealthtopics/antimicrobial_resistance/esac-net-database. Accessed 10 Nov 2016

  10. L’utilizzo di antibiotici e l’antibiotico-resistenza in Toscana (2015) Secondo report della Rete di Sorveglianza dell’Antibiotico Resistenza in Toscana (SART). https://www.ars.toscana.it/files/pubblicazioni/Volumi/2016/Documento_ARS_91_2017_18_gennaio_rev2.pdf. Accessed 15 Feb 2017

  11. Giamarellou H, Galani L, Baziaka F, Karaiskos I (2013) Effectiveness of a double-carbapenem regimen for infections in humans due to carbapenemase-producing pandrug-resistant K. pneumoniae. Antimicrob Agents Chemother 57(5):2388–2390. doi:10.1128/AAC.02399-12

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  12. Falcone M, Paterson D Spotlight on ceftazidime/avibactam: a new option for MDR Gram-negative infections. J Antimicrob Chemother 71(10):2713–2722. doi:10.1093/jac/dkw239

  13. Humphries RM, Yang S, Hemarajata P, Ward KW, Hindler JA, Miller SA, Gregson A (2015) First report of ceftazidime–avibactam resistance in a KPC-3-expressing Klebsiella pneumoniae isolate. Antimicrob Agents Chemother 59(10):6605–6607. doi:10.1128/AAC.01165-15

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  14. Choi MJ, Kim S, Ko KS (2016) Pathways regulating the pbgP operon and colistin resistance in Klebsiella pneumoniae strains. J Microbiol Biotechnol 26(9):1620–1628. doi:10.4014/jmb.1604.04016

    Article  PubMed  Google Scholar 

  15. Tascini C, Tagliaferri E, Giani T, Leonildi A, Flammini S, Casini B, Lewis R, Ferranti S, Rossolini GM, Menichetti F (2013) Synergistic activity of colistin plus rifampin against colistin-resistant KPC-producing Klebsiella pneumoniae. Antimicrob Agents Chemother 57(8):3990–3993. doi:10.1128/AAC.00179-13

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  16. Yin Y, Yue Z, Zhang Y, Li F, Zhang Q (2016) Over expression of AdeABC and AcrAB-TolC efflux systems confers tigecycline resistance in clinical isolates of Acinetobacter baumannii and Klebsiella pneumoniae. Rev Soc Bras Med Trop 49(2):165–171. doi:10.1590/0037-8682-0411-2015

    Article  Google Scholar 

  17. Bulik CC, Nicolau DP (2011) Double-carbapenem therapy for carbapenemase-producing K. pneumoniae. Antimicrob Agents Chemother 55(6):3002–3004. doi:10.1128/AAC.01420-10

  18. Morrill HJ, Pogue JM, Kaye KS, LaPlante KL (2015) Treatment options for carbapenem-resistant enterobacteriaceae infections. Open Forum Infect Dis. doi:10.1093/ofid/ofv050

    PubMed  PubMed Central  Google Scholar 

  19. Ceccarelli G, Falcone M, Giordano A, Mezzatesta ML, Caio C, Stefani S, Venditti M (2013) Successful ertapenem–doripenem combination treatment of bacteremic ventilator-associated pneumonia due to colistin-resistant KPC-producing K. pneumoniae. Antimicrob Agents Chemother 57(6):2900–2901. doi:10.1128/AAC.00188-13

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  20. Oliva A, D’Abramo A, D’Agostino C, Iannetta M, Mascellino MT, Gallinelli C, Mastroianni CM, Vullo V (2014) Synergistic activity and effectiveness of a double-carbapenem regimen in pandrug-resistant Klebsiella pneumoniae bloodstream infections. J Antimicrob Chemother 69(6):1718–1720. doi:10.1093/jac/dku027

    Article  CAS  PubMed  Google Scholar 

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Authors and Affiliations

  1. Intermediate Care Unit, Careggi University Hospital, Largo Brambilla, 3, 50141, Florence, Italy

    Filippo Pieralli, Silvia Baroncelli, Antonio Mancini, Fabio Luise & Lucia Sammicheli

  2. Infectious Diseases Clinic, Careggi University Hospital, Florence, Italy

    Alberto Farese & Alessandro Bartoloni

  3. Department of Medical Biotechnologies, University of Siena, Siena, Italy

    Gian Maria Rossolini

  4. Clinical Microbiology and Virology Unit, Careggi University Hospital, Florence, Italy

    Gian Maria Rossolini

  5. Emergency and Internal Medicine Department, Careggi University Hospital, Florence, Italy

    Carlo Nozzoli

Authors
  1. Filippo Pieralli
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  2. Silvia Baroncelli
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  3. Alberto Farese
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  4. Antonio Mancini
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  5. Fabio Luise
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  6. Lucia Sammicheli
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  7. Alessandro Bartoloni
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  8. Gian Maria Rossolini
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  9. Carlo Nozzoli
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Corresponding author

Correspondence to Silvia Baroncelli.

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The clinical case was managed in accordance to human rights as stated by the updated version of Helsinky declaration.

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Pieralli, F., Baroncelli, S., Farese, A. et al. Every cloud has a silver lining. Intern Emerg Med 12, 811–815 (2017). https://doi.org/10.1007/s11739-017-1675-z

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