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Internal and Emergency Medicine

, Volume 12, Issue 5, pp 621–627 | Cite as

Association between rheumatic diseases and cancer: results from a clinical practice cohort study

  • Mattia BellanEmail author
  • Enrico Boggio
  • Daniele Sola
  • Antonello Gibbin
  • Alessandro Gualerzi
  • Serena Favretto
  • Giulia Guaschino
  • Ramona Bonometti
  • Roberta Pedrazzoli
  • Mario Pirisi
  • Pier Paolo Sainaghi
IM - ORIGINAL

Abstract

The association between cancer and immune-mediated rheumatic conditions is controversial, especially as far as polymyalgia rheumatica (PMR) is concerned. Furthermore, no clinical feature has been shown to be suggestive of a paraneoplastic rheumatic syndrome. With the present study, we aim to address both these issues. The study population comprised N = 1750 patients, including N = 100 with PMR, who attended our tertiary immuno-rheumatology clinic between January 1, 2005 and November 30, 2012. A rheumatic disease was deemed paraneoplastic if cancer had been diagnosed in the 2 years preceding or following its onset. The probability of a significant association between a specific rheumatic disease and cancer was evaluated by computing the odds ratio (OR): N = 702 patients with osteoarthritis serving as controls. Furthermore, clinical features distinguishing paraneoplastic rheumatic diseases were searched for by univariate and multivariate analysis. Sjogren’s syndrome (SS) [OR 3.6 (CI 95% 1.7–7.5)], PMR (OR 5.1 CI 95% 2.9–8.9), dermatomyositis/polymyositis [OR 12.09 (CI 95% 2.6–55.8)] and vasculitis [OR 3.70 (CI 95% 1.81–7.52)] are associated with cancer. At multivariate analysis, older age is associated with cancer among SS patients (p = 0.03), while in the PMR group, older age, male gender, and ≥6 tender joints are independent predictors of paraneoplastic PMR (p < 0.0004). Cancer frequently either heralds or follows rheumatic manifestations, including PMR. Older age, male gender and a more extensive joint involvement should be considered red flags for paraneoplastic PMR.

Keywords

Rheumatic diseases Neoplasia Paraneoplastic syndromes Cancer 

Notes

Compliance with ethical standards

Conflict of interest

The authors have no conflict of interest to declare.

Statement of human and animal rights

All procedures performed in studies involving human partecipants were in accordance with the ethical standards of the institutional and/or national research committee and with the 1964 Helsinki declaration and its later amendments or comparable ethical standards.

Informed consent

For this type of study formal consent is not required.

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Copyright information

© SIMI 2017

Authors and Affiliations

  • Mattia Bellan
    • 1
    • 2
    Email author
  • Enrico Boggio
    • 1
  • Daniele Sola
    • 1
    • 2
  • Antonello Gibbin
    • 1
    • 2
  • Alessandro Gualerzi
    • 1
    • 2
  • Serena Favretto
    • 1
    • 2
  • Giulia Guaschino
    • 1
    • 2
  • Ramona Bonometti
    • 1
    • 2
  • Roberta Pedrazzoli
    • 2
  • Mario Pirisi
    • 1
    • 2
    • 3
  • Pier Paolo Sainaghi
    • 2
    • 3
  1. 1.Department of Translational MedicineUniversità del Piemonte Orientale UPONovaraItaly
  2. 2.Division of Internal Medicine, Immunorheumatology Unit“Maggiore della Carità” HospitalNovaraItaly
  3. 3.IRCAD, Interdisciplinary Research Center of Autoimmune DiseasesNovaraItaly

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