Internal and Emergency Medicine

, Volume 12, Issue 1, pp 9–11 | Cite as

NETosis in arterial and venous thrombosis: a one size fits all mechanism?

  • Erica De CandiaEmail author

In their review, Mozzini et al. [1] highlight how several epidemiological studies have suggested associations between venous thromboembolism and atherosclerosis. Likely, common risk factors and biological mechanisms account for this association. In this context, the authors provide some evidences suggesting that NETosis might contribute to similarities between venous and arterial thrombotic disorders.

NETosis is the process of the release of web-like structures of DNA by activated neutrophils, named neutrophil extracellular traps (NETs), which can trap and kill microbes in tissues. This newly described mechanism of innate immune defense against infections ensures neutrophil anti-bacterial activity in addition to the more traditional mechanism of phagocytosis. An important seminal study by Brinkman et al. [2] showed that lipopolysaccharide induced the extrusion, from the cytoplasm of neutrophils, of fibrillar material that is made of condensed chromatin and DNA, and can be digested by...


Deep Vein Thrombosis Calcify Coronary Artery Citrullinated Neutrophil Extracellular Trap Coronary Artery Atherosclerosis 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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Conflict of interest

The authors declare that they have no conflict of interest.

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This article does not contain any studies with human participants or animals performed by any of the authors.

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© SIMI 2017

Authors and Affiliations

  1. 1.Servizio Malattie Emorragiche e Trombotiche, Area di Ematologia, Fondazione Policlinico Agostino Gemelli, Istituto di Medicina InternaUniversità Cattolica del Sacro CuoreRomeItaly

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