NETosis in arterial and venous thrombosis: a one size fits all mechanism?
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In their review, Mozzini et al.  highlight how several epidemiological studies have suggested associations between venous thromboembolism and atherosclerosis. Likely, common risk factors and biological mechanisms account for this association. In this context, the authors provide some evidences suggesting that NETosis might contribute to similarities between venous and arterial thrombotic disorders.
NETosis is the process of the release of web-like structures of DNA by activated neutrophils, named neutrophil extracellular traps (NETs), which can trap and kill microbes in tissues. This newly described mechanism of innate immune defense against infections ensures neutrophil anti-bacterial activity in addition to the more traditional mechanism of phagocytosis. An important seminal study by Brinkman et al.  showed that lipopolysaccharide induced the extrusion, from the cytoplasm of neutrophils, of fibrillar material that is made of condensed chromatin and DNA, and can be digested by...
KeywordsDeep Vein Thrombosis Calcify Coronary Artery Citrullinated Neutrophil Extracellular Trap Coronary Artery Atherosclerosis
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This article does not contain any studies with human participants or animals performed by any of the authors.
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