Skip to main content
SpringerLink
Log in

Does early onset cataract increase the risk of ischemic stroke? A nationwide retrospective cohort study

  • IM - ORIGINAL
  • Published:
Internal and Emergency Medicine Aims and scope Submit manuscript

Abstract

This study was attempted to address the association between early onset cataract (EOC) and ischemic stroke. Using the Longitudinal Health Insurance Database 2000, we established an EOC cohort and a comparison cohort by using 4-fold propensity score matching according to age, gender and comorbidities to detect the incidence of ischemic stroke. A Cox model was used to express the risk of ischemic stroke for the EOC patients compared with the comparison cohort. After adjusting for age, gender and comorbidities of hypertension, diabetes mellitus, hyperlipidemia, coronary artery disease, asthma, chronic obstructive pulmonary disease, chronic kidney disease, heart failure, obesity, and atrial fibrillation, the EOC patients had a 1.48-fold higher risk of ischemic stroke than the comparison cohort, but it was not statistically significant. A non-significant increase in the risk of subsequent ischemic stroke development for the EOC patients is demonstrated in this study.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

References

  1. Christen WG, Glynn RJ, Chew EY, Albert CM, Manson JE (2016) Folic acid, vitamin B, and vitamin B in combination and age-related cataract in a randomized trial of women. Ophthalmic Epidemiol 23:32–39

    Article  PubMed  PubMed Central  Google Scholar 

  2. Mares J (2015) Food antioxidants to prevent cataract. JAMA 313:1048–1049

    Article  CAS  PubMed  Google Scholar 

  3. Kruk J, Kubasik-Kladna K, Aboul-Enein HY (2015) The role oxidative stress in the pathogenesis of eye diseases: current status and a dual role of physical activity. Mini Rev Med Chem. 16:241–257

    Article  PubMed  Google Scholar 

  4. Rautiainen S, Lindblad BE, Morgenstern R, Wolk A (2014) Total antioxidant capacity of the diet and risk of age-related cataract: a population-based prospective cohort of women. JAMA Ophthalmol. 132:247–252

    Article  PubMed  Google Scholar 

  5. Hu FB, Hankinson SE, Stampfer MJ, Manson JE, Colditz GA, Speizer FE et al (2001) Prospective study of cataract extraction and risk of coronary heart disease in women. Am J Epidemiol 153:875–881

    Article  CAS  PubMed  Google Scholar 

  6. Trevithick JR, Mitton KP (2000) Vitamin C and E in cataract risk reduction. Int Ophthalmol Clin 40:59–69

    Article  CAS  PubMed  Google Scholar 

  7. Nemet AY, Vinker S, Levartovsky S, Kaiserman I (2010) Is cataract associated with cardiovascular morbidity? Eye (Lond). 24:1352–1358

    Article  CAS  PubMed  Google Scholar 

  8. Lindblad BE, Håkansson N, Philipson B, Wolk A (2008) Metabolic syndrome components in relation to risk of cataract extraction: a prospective cohort study of women. Ophthalmology 115:1687–1692

    Article  PubMed  Google Scholar 

  9. Goodrich ME, Cumming RG, Mitchell P, Koutts J, Burnett L (1999) Plasma fibrinogen and other cardiovascular disease risk factors and cataract. Ophthalmic Epidemiol 6:279–290

    Article  CAS  PubMed  Google Scholar 

  10. Podgor MJ, Kannel WB, Cassel GH, Sperduto RD (1989) Lens changes and the incidence of cardiovascular events among persons with diabetes. Am Heart J 117:642–648

    Article  CAS  PubMed  Google Scholar 

  11. Feigin VL, Forouzanfar MH, Krishnamurthi R, Mensah GA, Connor M, Bennett DA et al (2014) Global Burden of Diseases, Injuries, and Risk Factors Study 2010 (GBD 2010) and the GBD Stroke Experts Group. Global and regional burden of stroke during 1990–2010: findings from the Global Burden of Disease Study 2010. Lancet 383:245–254

    Article  PubMed  PubMed Central  Google Scholar 

  12. Lozano R, Naghavi M, Foreman K, Lim S, Shibuya K, Aboyans V et al (2012) Global and regional mortality from 235 causes of death for 20 age groups in 1990 and 2010: a systematic analysis for the Global Burden of Disease Study 2010. Lancet 380:2095–2128

    Article  PubMed  Google Scholar 

  13. Goldstein LB, Bushnell CD, Adams RJ, Appel LJ, Braun LT, Chaturvedi S, American Heart Association Stroke Council, Council on Cardiovascular Nursing, Council on Epidemiology and Prevention, Council for High Blood Pressure Research, Council on Peripheral Vascular Disease, and Interdisciplinary Council on Quality of Care and Outcomes Research et al (2011) Guidelines for the primary prevention of stroke: a guideline for healthcare professionals from the American Heart Association/American Stroke Association. Stroke 42:517–584

    Article  PubMed  Google Scholar 

  14. Lloyd-Jones D, Adams RJ, Brown TM, Carnethon M, Dai S, De Simone G, Writing Group Members et al (2010) American Heart Association Statistics Committee and Stroke Statistics Subcommittee. Heart disease and stroke statistics-2010 update: a report from the American Heart Association. Circulation 121:e46–e215

    Article  PubMed  Google Scholar 

  15. O’Donnell MJ, Xavier D, Liu L, Zhang H, Chin SL, Rao-Melacini P, INTERSTROKE investigators et al (2010) Risk factors for ischaemic and intracerebral haemorrhagic stroke in 22 countries (the INTERSTROKE study): a case-control study. Lancet 376:112–123

    Article  PubMed  Google Scholar 

  16. WHO (2008) The Global Burden of disease: 2004 update. WHO, Geneva

    Google Scholar 

  17. Strong K, Mathers C, Bonita R (2007) Preventing stroke: saving lives around the world. Lancet Neurol 6:182–187

    Article  PubMed  Google Scholar 

  18. Murray CJ, Lopez AD (1997) Mortality by cause for eight regions of the world: global burden of disease study. Lancet 349:1269–1276

    Article  CAS  PubMed  Google Scholar 

  19. National Health Research Institutes. National Health Insurance Research Database. Available at: http://nhird.nhri.org.tw/en/index.html. Accessed 14 Apr 2015

  20. Hu WS, Lin CL, Chang SS, Chen MF, Chang KC (2016) Increased risk of ischemic heart disease among subjects with cataracts: a population-based cohort study. Medicine (Baltimore). 95(28):e4119

    Article  PubMed  PubMed Central  Google Scholar 

  21. Hu WS, Lin CL, Huang CY, Chang SS, Chang KC (2016) Cataract increases the risk of peripheral artery occlusive disease: a nationwide population-based cohort study with propensity score. Int J Cardiol 1(220):768–771

    Article  Google Scholar 

  22. Delbari A, Keyghobadi F, Momtaz YA, Keyghobadi F, Akbari R, Kamranian H, Yazdi MS, Tabatabaei SS, Fereshtehnejad SM (2016) Sex differences in stroke: a socioeconomic perspective. Clin Interv Aging 11:1207–1212

    Article  PubMed  PubMed Central  Google Scholar 

  23. Santalucia P, Pezzella FR, Sessa M, Monaco S, Torgano G, Anticoli S, Zanoli E, Maimone Baronello M, Paciaroni M, Caso V (2013) Women Stroke Association (WSA). Sex differences in clinical presentation, severity and outcome of stroke: results from a hospital-based registry. Eur J Intern Med. 24(2):167–171

    Article  CAS  PubMed  Google Scholar 

  24. Haast RA, Gustafson DR, Kiliaan AJ (2012) Sex differences in stroke. J Cereb Blood Flow Metab 32(12):2100–2107

    Article  PubMed  PubMed Central  Google Scholar 

  25. Cheng CL, Kao YH, Lin SJ, Lee CH, Lai ML (2011) Validation of the national health insurance research database with ischemic stroke cases in Taiwan. Pharmacoepidemiol Drug Saf 20:236–242

    Article  PubMed  Google Scholar 

  26. Lu JF, Hsiao WC (2003) Does universal health insurance make health care unaffordable? Lessons from Taiwan. Health Aff (Millwood). 22:77–88

    Article  PubMed  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Graduate Institute of Basic Medical Science, China Medical University, Taichung, 40402, Taiwan

    Chih-Yang Huang & Tung-Sheng Chen

  2. Department of Health and Nutrition Biotechnology, Asia University, Taichung, 41354, Taiwan

    Chih-Yang Huang

  3. Biomaterials Translational Research Center, China Medical University Hospital, Taichung, 40402, Taiwan

    Tung-Sheng Chen

  4. Management Office for Health Data, China Medical University Hospital, Taichung, 40447, Taiwan

    Cheng-Li Lin

  5. School of Medicine, College of Medicine, China Medical University, Taichung, 40402, Taiwan

    Wei-Syun Hu

  6. Division of Cardiovascular Medicine, Department of Medicine, China Medical University Hospital, 2, Yuh-Der Road, Taichung, 40447, Taiwan

    Wei-Syun Hu

Authors
  1. Chih-Yang Huang
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Tung-Sheng Chen
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Cheng-Li Lin
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Wei-Syun Hu
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Wei-Syun Hu.

Ethics declarations

Conflict of interest

The authors declare that they have no conflict of interest.

Statement of human and animal rights

This article does not contain any studies with human participants or animals performed by any of the authors.

Informed consent

None.

Sponsor’s role

This study is supported in part by Taiwan Ministry of Health and Welfare Clinical Trial and Research Center of Excellence (MOHW105-TDU-B-212-133019), China Medical University Hospital, Academia Sinica Taiwan Biobank Stroke Biosignature Project (BM10501010037), NRPB Stroke Clinical Trial Consortium (MOST 104-2325-B-039 -005), Tseng-Lien Lin Foundation, Taichung, Taiwan, Taiwan Brain Disease Foundation, Taipei, Taiwan, and Katsuzo and Kiyo Aoshima Memorial Funds, Japan. This funding source and sponsor had no role in the design of this study, and will not have any role during its execution, analyses, interpretation of the data, or decision to submit results.

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Huang, CY., Chen, TS., Lin, CL. et al. Does early onset cataract increase the risk of ischemic stroke? A nationwide retrospective cohort study. Intern Emerg Med 12, 461–465 (2017). https://doi.org/10.1007/s11739-016-1591-7

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s11739-016-1591-7

Keywords

Search

Navigation