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Infectious complications in neutropenic cancer patients

  • Symposium: Managing of Complications in Patients with Cancer
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Abstract

Cancer patients are at risk of infectious complications due to neutropenia following chemotherapy or early post-HSCT (Hemato Stem Cell Transplantation). The first episode of fever during recent onset neutropenia is caused mostly by bacteria, while subsequent episodes are mainly fungal in nature. Proper management of infectious complications in neutropenic cancer patients requires classification into the appropriate risk category and knowledge of the local epidemiology of infections, of the causative organisms and their resistance phenotype.

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References

  1. Pizzo PA (1999) Fever in immunocompromised patients. N Engl J Med 341:893–900

    Article  CAS  PubMed  Google Scholar 

  2. Cullen M, Steven N, Billingham L, Gaunt C, Hastings M, Simmonds P et al (2005) Antibacterial prophylaxis after chemotherapy for solid tumors and lymphomas. N Engl J Med 353(10):988–998

    Article  CAS  PubMed  Google Scholar 

  3. Bucaneve G, Micozzi A, Menicheti F, Martino P, Dionisi MS, Martinelli G et al (2005) Levofloxacin to prevent bacterial infection in patients with cancer and neutropenia. N Engl J Med 353(10):977–987

    Article  CAS  PubMed  Google Scholar 

  4. Gafter-Gvili A, Fraser A, Paul M, Leibovici L (2005) Meta-analysis: antibiotic prophylaxis reduces mortality in neutropenic patients. Ann Intern Med 142:979–995

    PubMed  Google Scholar 

  5. Walsh T et al (1999) Liposomal amphotericin B for empirical therapy in patients with persistent fever and neutropenia. N Engl J Med 340:764–771

    Article  CAS  PubMed  Google Scholar 

  6. Maertens J, Theunissen K, Verhoef G, Verschakelen J, Lagrou K, Verbeken E et al (2005) Galactomannan and computed tomography-based preemptive antifungal therapy in neutropenic patients at high risk for invasive fungal infection: a prospective feasibility study. Clin Infect Dis 41(9):1242–1250

    Google Scholar 

  7. Cordonnier C, Pautas C, Maury S, Vekhoff A, Farhat H, Suarez F et al (2009) Empirical versus preemptive antifungal therapy for high-risk, febrile, neutropenic patients: a randomized, controlled trial. Clin Infect Dis 48(8):1042–1051

    Google Scholar 

  8. Cornely OA, Bohme A, Buchheidt D, Einsele H, Heinz WJ, Karthaus M et al (2009) Primary prophylaxis of invasive fungal infections in patients with hematologic malignancies. Recommendations of the Infectious Diseases Working Party of the German Society for Hematology and Oncology. Haematologica 94(1):113–122

    Google Scholar 

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Correspondence to Francesco Menichetti.

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Menichetti, F. Infectious complications in neutropenic cancer patients. Intern Emerg Med 5 (Suppl 1), 21–25 (2010). https://doi.org/10.1007/s11739-010-0456-8

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  • DOI: https://doi.org/10.1007/s11739-010-0456-8

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