Erratum to: Intern Emerg Med DOI 10.1007/s11739-009-0283-y

Unfortunately, the two sentences under the sections “Classification, structure, and regulation” (ninth paragraph: The activation of a pro-MMP is the…) and “MMPs and diabetes” (second paragraph: In fact, an upregulation of MMP-2 and -9 in the human…) in the present form are wrong. Please find the correct sentences here.

“The principal way for the activation of pro-MMPs is by the removal of its propeptide domain by tissue or plasmatic proteinases, including active MMPs. Moreover, pro-MMP activation can occur at the surface of cells, as in the case of MMP-2, or at intracellular level, as in the case of MMP-11, -21, -23, -27 and MT-MMPs.”

“In fact, an upregulation of MMP-2 and -9, which induce the expression of angiostatin, has been shown in the arterial vasculature of diabetics, suggesting that the enhanced production of angiostatin, a potent anti-angiogenic factor that antagonizes the expression and the activity of VEGF [61, 62], may explain the impaired angiogenesis of diabetes [63].”