Selecting references that match constructs: the difficult job of citing the parachute hyperbole

  • Alfonso Iorio
  • Lorenzo MojaEmail author
  • Alessandro Liberati
  • Gian Franco Gensini
  • Roberto Gusinu
  • Andrea A. Conti
CE - Cochrane's Corner

The methodologist’s point of view

Alfonso Iorio, Lorenzo Moja, Alessandro Liberati

The large scale availability of clotting factor concentrates and the organization of comprehensive care centres prompted a progressive increase in the life expectancy and quality of life of western world haemophilia patients [1, 2]. The best treatment regimen for haemophilia, across the world being considered, is regular prophylactic replacement with clotting factor concentrates. Strong observational evidence has been available since long time in support of this widely established pattern of practice; 26 unique observational studies of varying quality for a total of 1,612 patients on prophylaxis compared to 1,191 patients treated on-demand were reported through 2005 [3]. Notwithstanding this evidence and in front of several open questions about optimization of prophylactic regimen (i.e., onset, frequency, intensity, duration, patient selection), the directors of the Canadian Association of Haemophilia...


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Copyright information

© SIMI 2008

Authors and Affiliations

  • Alfonso Iorio
    • 1
  • Lorenzo Moja
    • 2
    Email author
  • Alessandro Liberati
    • 2
  • Gian Franco Gensini
    • 3
  • Roberto Gusinu
    • 4
  • Andrea A. Conti
    • 5
  1. 1.Stroke Unit and Division of Cardiovascular Medicine, Department of Internal MedicineUniversity of PerugiaPerugiaItaly
  2. 2.Italian Cochrane CentreMario Negri Institute for Pharmacological ResearchMilanItaly
  3. 3.Department of Critical Care Medicine and SurgeryUniversity of Florence and Azienda Ospedaliero-Universitaria CareggiFlorenceItaly
  4. 4.DAI Cardiologico e dei VasiAzienda Ospedaliero-Universitaria CareggiFlorenceItaly
  5. 5.Department of Critical Care Medicine and SurgeryUniversity of Florence and Don Carlo Gnocchi Foundation IRCCSFlorenceItaly

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