Selecting references that match constructs: the difficult job of citing the parachute hyperbole
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The methodologist’s point of view
Alfonso Iorio, Lorenzo Moja, Alessandro Liberati
The large scale availability of clotting factor concentrates and the organization of comprehensive care centres prompted a progressive increase in the life expectancy and quality of life of western world haemophilia patients [1, 2]. The best treatment regimen for haemophilia, across the world being considered, is regular prophylactic replacement with clotting factor concentrates. Strong observational evidence has been available since long time in support of this widely established pattern of practice; 26 unique observational studies of varying quality for a total of 1,612 patients on prophylaxis compared to 1,191 patients treated on-demand were reported through 2005 . Notwithstanding this evidence and in front of several open questions about optimization of prophylactic regimen (i.e., onset, frequency, intensity, duration, patient selection), the directors of the Canadian Association of Haemophilia...
- 3.Stobart K, Iorio A, Wu J (2006) Clotting factor concentrates given to prevent bleeding and bleeding-related complications in people with hemophilia A or B. Cochrane Database of Systematic Reviews 2006, Issue 2. Art. No.: CD003429. doi: 10.1002/14651858.CD003429.pub3
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