Internal and Emergency Medicine

, Volume 3, Issue 2, pp 171–173 | Cite as

Successful outcome of DIC and life-threatening bleeding in a toddler with neuroblastoma treated with recombinant activated factor VII

  • Emmanouil S. Hatzipantelis
  • Nikolaos GombakisEmail author
  • Vasiliki Sidi
  • Evgenia Papakonstantinou
  • Dimitrios E. Koliouskas
CE - Letter to the Editor

Bleeding in disseminated intravascular coagulation (DIC) associated with advanced or metastatic tumors is often difficult to control by conventional methods [1]. The standard treatment includes red blood cells, (RBC), fresh frozen plasma (FFP), cryoprecipitate, and platelet concentrates. However, such replacement therapy is associated with increased risks of morbidity and mortality [2]. Sallah et al. [1] reported the use of rFVIIa in 18 patients with cancer and bleeding secondary to DIC; 15 of them responded to the treatment with improvement in coagulation laboratory data and arrest in bleeding. Here we report on the use of rFVIIa in a 16-month-old boy with metastatic bilateral neuroblastoma and massive bleeding secondary to DIC.

The boy presented with pallor and abdominal distension, due to a large palpable mass. Image studies revealed an unresectable extending bilaterally tumor with lymph node involvement and bone marrow infiltration. Fine-needle biopsy confirmed the diagnosis of...


Neuroblastoma Tissue Factor Disseminate Intravascular Coagulation Fresh Freeze Plasma Fresh Freeze Plasma 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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Copyright information

© SIMI 2008

Authors and Affiliations

  • Emmanouil S. Hatzipantelis
    • 1
  • Nikolaos Gombakis
    • 2
    Email author
  • Vasiliki Sidi
    • 1
  • Evgenia Papakonstantinou
    • 1
  • Dimitrios E. Koliouskas
    • 1
  1. 1.Paediatric Oncology Department“Hippokration” General Hospital of ThessalonikiThessalonikiGreece
  2. 2.1st Paediatric Department of Aristotle University of Thessaloniki“Hippokration” General HospitalThessalonikiGreece

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