Successful outcome of DIC and life-threatening bleeding in a toddler with neuroblastoma treated with recombinant activated factor VII
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Bleeding in disseminated intravascular coagulation (DIC) associated with advanced or metastatic tumors is often difficult to control by conventional methods . The standard treatment includes red blood cells, (RBC), fresh frozen plasma (FFP), cryoprecipitate, and platelet concentrates. However, such replacement therapy is associated with increased risks of morbidity and mortality . Sallah et al.  reported the use of rFVIIa in 18 patients with cancer and bleeding secondary to DIC; 15 of them responded to the treatment with improvement in coagulation laboratory data and arrest in bleeding. Here we report on the use of rFVIIa in a 16-month-old boy with metastatic bilateral neuroblastoma and massive bleeding secondary to DIC.
KeywordsNeuroblastoma Tissue Factor Disseminate Intravascular Coagulation Fresh Freeze Plasma Fresh Freeze Plasma
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