Internal and Emergency Medicine

, Volume 3, Issue 2, pp 161–163 | Cite as

Acute tumor lysis syndrome after rituximab administration in Burkitt’s lymphoma

  • Zaher K. Otrock
  • Hassan A. Hatoum
  • Ziad M. SalemEmail author
CE - Letter to the Editor

Rituximab (Rituxan, Mabthera) is an anti-CD20 monoclonal antibody that mediates killing of CD20+ B-lymphocytes by a combination of complement-mediated lysis and antibody-dependent cytotoxicity [1]. It is considered a safe medication, and infusion-related side effects are generally manageable. These include fever, chills and rigors, and they occur in 50% of patients [2]. Rituximab has been considered a nontoxic alternative to chemotherapy regimens and has become part of standard therapy for patients with CD20-expressing B-cell lymphoma [3]. In patients with a large number of CD20+ cells, tumor lysis may occur. Acute tumor lysis syndrome (TLS) caused by rituximab has been reported in two patients with chronic lymphocytic leukemia [4, 5] and in three patients with non-Hodgkin’s lymphoma (NHL) [4, 6, 7]. We report another case of a patient with Burkitt’s lymphoma who experienced acute TLS upon treatment with rituximab.

A 53-year-old man presented to a hospital in Saudi Arabia in January...


Uric Acid Chronic Lymphocytic Leukemia Bone Marrow Aspirate Tumor Lysis Syndrome Autoimmune Hemolytic Anemia 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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Copyright information

© SIMI 2008

Authors and Affiliations

  • Zaher K. Otrock
    • 1
  • Hassan A. Hatoum
    • 1
  • Ziad M. Salem
    • 1
    Email author
  1. 1.Division of Hematology/Oncology, Department of Internal MedicineAmerican University of Beirut Medical CenterBeirutLebanon

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