Overview of reported transcutaneous electrical acupoint stimulation effects on pain mediators

经皮穴位电刺激对疼痛介质影响的研究概况

Abstract

Literatures on pain intervention with transcutaneous electrical acupoint stimulation (TEAS) were collected by searching the databases both in Chinese and English, and summarized to understand the research progress of TEAS effects on pain mediators in recent years. This will provide a more objective and scientific theoretical basis for clinical practice of TEAS to treat pain syndrome, thus promoting the clinical application of TEAS. Our literature analysis indicated that TEAS effectively regulated the release levels of various pain factors such as prostaglandin, 5-hydroxytryptamine, interleukins, substance P and tumor necrosis factor-α to achieve the analgesic effects by affecting the conduction pathways. TEAS is a safe, non-invasive and effective treatment for pain syndrome. However, further research is necessary due to the lack of rigor of the current clinical trial design.

【摘要】

通过检索中英文数据库获取有关经皮穴位电刺激干预痛证的相关文献, 并进行整理归纳, 从而了解近年 来经皮穴位电刺激对疼痛介质影响的研究进展, 为临床采用经皮穴位电刺激治疗痛证提供更客观、科学的理论依 据, 促进经皮穴位电刺激的临床应用。文献分析结果表明经皮穴位电刺激可有效调控前列腺素、5-羟色胺、白介 素、P 物质、肿瘤坏死因子α 等多种疼痛因子的释放水平, 影响其传导通路, 从而起到镇痛效果; 经皮穴位电刺 激是一种安全、无创、有效的痛证治疗手段。但当前临床试验设计欠严谨, 研究仍需进一步深入。

This is a preview of subscription content, access via your institution.

References

  1. [1]

    Xie JJ, Wang D, Fang JQ. Comparison on regulatory effects of transcutaneous electrical acupoint stimulation of different points on pain threshold and blood pressure of rats. Zhonghua Zhongyiyao Zazhi, 2015, 30(11): 4144–4146.

    Google Scholar 

  2. [2]

    Chao M, Liang F, Wang Z, Wang L, Wang XD. Research progress in clinical application of transcutaneous electrical acupoint stimulation in chronic diseases. Zhongguo Kangfu Yixue Zazhi, 2016, 31(6): 710–714.

    Google Scholar 

  3. [3]

    Wu LH, Dong MS, Fang JQ, Sheng ZM, Wu YL. Effect of exercise-induced fatigue and recovery with preventive of acupuncture and moxibustion at ‘Zusanli’ (ST 36) point on intensive military training men. Zhejiang Zhongyiyao Daxue Xuebao, 2014, 38(10): 1217–1220.

    Google Scholar 

  4. [4]

    Shi JJ, Huang LF. Effects of transcutaneous electrical acupoint stimulation of ‘Zusanli’ (ST 36) on gastric mucosal injury in exercise stress-induced gastric ulcer rats. Zhen Ci Yan Jiu, 2013, 38(3): 181–185.

    CAS  PubMed  Google Scholar 

  5. [5]

    You SJ, Xia Y, Li Y, Ju ZY, He JS. Effect of transcutaneous electrical acupoint stimulation on skeletal muscle energy metabolism in strenuous endurance training rats. Shanghai Zhenjiu Zazhi, 2011, 30(3): 192–194.

    Google Scholar 

  6. [6]

    You SJ, Xia Y, Li Y, Ju ZY, He JS. Effects of the transcutanclus electrical acupoint stimulation on the NO, TNOS and INOS levels of skeletal muscle in rats during extensive endurance training. Zhongguo Yundong Yixue Zazhi, 2011, 30(5): 448–451.

    CAS  Google Scholar 

  7. [7]

    Shen FF, Xia ZM, Zhang YM. Clinical observation on analgesic effect of percutaneous electrical stimulation on postoperative mixed hemorrhoids. Yixue Zongshu, 2020, 26(4): 805–808.

    Google Scholar 

  8. [8]

    Liu J, Qiu D, Tan X, Zuo L, Qin JJ, Li RM. Observation of the efficacy of transcutaneous electric nerve stimulation in labor analgesia. Jinan Daxue Xuebao (Ziran Kexue Yu Yixue Ban), 2016, 37(5): 416–419.

    Google Scholar 

  9. [9]

    Huang YQ, Lei WP, Xiao C, Sun JL. Effects of transcutaneous electrical nerve stimulation on the activation of spinal extracellular signal regulated kinases 1/2 in acute visceral pain rats. Shanghai Yixue, 2016, 39(2): 108–111, 129.

    CAS  Google Scholar 

  10. [10]

    Jin Y, Guo HY, He HJ, Han JS, Zhu FL, Liang HM, Kong DL. Transcutaneous electrical acupoint stimulation in the treatment of chronic pelvic pain and dysmenorrhea in female patients: a pilot trial. Zhongguo Fuchanke Linchuang Zazhi, 2015, 16(5): 410–412.

    Google Scholar 

  11. [11]

    Wang CY, Fang JQ. Cancer pain treated with transcutaneous electrical acupoint stimulation. Zhejiang Zhongyi Zazhi, 2011, 46(12): 899.

    Google Scholar 

  12. [12]

    Melzack R, Wall PD. Pain mechanisms: a new theory. Surv Anesthesiol, 1967, 11: 89–90.

    Article  Google Scholar 

  13. [13]

    Lu Y, Dong HL, Gao YD, Gong YY, Ren YN, Gu N, Zhou SD, Xia N, Sun YY, Ji RR, Xiong LZ. A feed-forward spinal cord glycinergic neural circuit gates mechanical allodynia. J Clin Invest, 2013, 123(9): 4050–4062.

    CAS  PubMed  PubMed Central  Article  Google Scholar 

  14. [14]

    Duan B, Cheng LZ, Bourane S, Britz O, Padilla C, Garcia-Campmany L, Krashes M, Knowlton W, Velasquez T, Ren XY, Ross SE, Lowell BB, Wang Y, Goulding M, Ma QF. Identification of spinal circuits transmitting and gating mechanical pain. Cell, 2014, 159(6): 1417–1432.

    CAS  PubMed  PubMed Central  Article  Google Scholar 

  15. [15]

    Kawakita K, Shinbara H, Imai K, Fukuda F, Yano T, Kuriyama K. How do acupuncture and moxibustion act? Focusing on the progress in Japanese acupuncture research. J Pharmacol Sci, 2006, 100(5): 443–459.

    CAS  PubMed  Article  Google Scholar 

  16. [16]

    Fei H, Xie GX, Han JS. Low and high frequency electroacupuncture stimulation release met-enkephalin and dynorphin A in rat spinal cord. Chin Sci Bull, 1987, 32: 1496–1501.

    CAS  Article  Google Scholar 

  17. [17]

    Chen XH, Guo SF, Chang CG, Han JS. Optimal conditions for eliciting maximal electroacupuncture analgesia with dense-and-sparse mode stimulation. Am J Acupunct, 1994, 22: 47–53.

    Google Scholar 

  18. [18]

    Fu CM, Wang M, Xu ST, Jin SJ. Effects of analgesic and anti-inflammatory of sophocarpine and related COX-2/PGE2 signaling pathway. Zhongguo Yaofang, 2019, 30(13): 1775–1780.

    Google Scholar 

  19. [19]

    Ke JH, Xu SY, Zhan GH, Lei LH, Xu YL, Lin JH, Chen WD. Transcutaneous electrical acupoint stimulation combined with ultrasound guided sacral block in the treatment of severe primary dysmenorrhea. Zhejiang Chuangshang Waike, 2017, 22(5): 840–842.

    Google Scholar 

  20. [20]

    Jia Y, Chen B, Cai SX, Li P, Yang Q, Wu XF. Preventive and therapeutic effects of TEAS on rabbits with orthodontic toothache. Zhongguo Zhen Jiu, 2016, 36(11): 1186–1190.

    PubMed  Google Scholar 

  21. [21]

    Jiang B, Yang QH, Sun ZH, Bai ZT. The role of spinal 5-HT2A receptor in pathological pain. Yan’an Daxue Xuebao (Ziran Kexue Ban), 2015, 34(1): 37–39, 45.

    Google Scholar 

  22. [22]

    Liu LL, Wang PZ, Xiong JY, Liu SN, Feng MN, Liao CB, Lei EJ. Research status and function of 5-HT system in pain regulation mechanism. Nanchang Daxue Xuebao (Yixue Ban), 2015, 55(5): 94–96, 104.

    Google Scholar 

  23. [23]

    Liu W. Role of 5-HT Receptors in Activation of Astroglia in the Spinal Dorsal Horn in A Rat Model of Neuropathic Pain. Chongqing: Master Thesis of Chongqing Yike Daxue, 2011.

    Google Scholar 

  24. [24]

    Jia Y, Chen B, Cai SX, Li P, Yang Q, Wu XF. Effect of transcutaneous electrical acupoint stimulation on peripheral and central pain regulators 5-hydroxytryptamine and substance P in orthodontic rabbits. Zhongguo Laonianxue Zazhi, 2016, 36(12): 2844–2845.

    CAS  Google Scholar 

  25. [25]

    Xie TF, Liu CA, Liu J. Determination of histamine and 5-HT levels of mouse brain using HPLC-MS/MS. Hefei Gongye Daxue Xuebao (Ziran Kexue Ban), 2018, 41(1): 124–128.

    Google Scholar 

  26. [26]

    Lan L, Shen L, Huang YG. Roles of inflammatory reaction and cytokines in chronic postsurgical pain. Zhongguo Yixue Kexueyuan Xuebao, 2015, 37(6): 741–745.

    CAS  PubMed  Google Scholar 

  27. [27]

    Zhang HJ, Xu M, Zhang XQ, Ma HX. Effect of stellate ganglion block on postoperative analgesia, lL-8 and IL-10 in abdominal operation. Zhongguo Xiandai Yiyao Zazhi, 2016, 18(9): 16–19.

    CAS  Google Scholar 

  28. [28]

    Wang L, Liu F, Hao HN, Xue R, Wang B. Effect of transcutaneous electrical acupoint stimulation combined with Shen Ling Bai Zhu powder on gastrointestinal function and serum inflammatory factor levels after general anesthesia for ovarian cancer. Xiandai Zhongxiyi Jiehe Zazhi, 2018, 27(20): 2211–2214.

    Google Scholar 

  29. [29]

    Yang LL, Mo YC, Wang LL, Wang JL. The effect of transcutaneous electrical acupoint stimulation on the complications and inflammatory factors after laparoscopic cholecystectomy. Zhejiang Zhongyi Zazhi, 2016, 51(1): 9–10.

    CAS  Google Scholar 

  30. [30]

    Du HR. Study on effect of transcutaneous electrical acupoint stimulation on immune function in perioperative patients with lung cancer. Xiandai Zhongxiyi Jiehe Zazhi, 2015, 24(36): 4010–4013.

    CAS  Google Scholar 

  31. [31]

    Chen WY, Li L, Wang HY, Jiang N. Effects of transcutaneous electrical acupoint stimulation for depression in late pregnancy and impacts on inflammatory cytokines. Zhen Ci Yan Jiu, 2018, 43(1): 43–47.

    Google Scholar 

  32. [32]

    Wang JL, Ren QS, Shen CC, Xie WX, Zhen RX, Ni JW. Effect of transcutaneous acupoint electrical stimulation on blood bioactive compounds involving cerebral injury during craniotomy. Zhen Ci Yan Jiu, 2008, 33(1): 26–30.

    CAS  PubMed  PubMed Central  Google Scholar 

  33. [33]

    Zhang LY, Yu J, Song X, Song PC. Analysis of pain mediators and inflammatory factors of patients with lumber disc herniation after percutaneous transforaminal endoscopic discectomy. Ningxia Yike Daxue Xuebao, 2018, 40(11): 1288–1292.

    Google Scholar 

  34. [34]

    Bao TX, Zhao JY, Tang XS. Correlation between SP, CGRP, IL-6 and distant pain with thoracolumbar compressive fracture. Zhongguo Gu Yu Guanjie Sunshang Zazhi, 2015, 30(5): 500–503.

    Google Scholar 

  35. [35]

    Tu Q, Shi JL, Yu H, Zhang S, Gu SH, Gan JH. Effect of transcutaneous electrical acupoint stimulation on postoperative analgesia of ureteroscopic holmium laser lithotripsy. Zhongguo Zhen Jiu, 2018, 38(7): 711–715.

    PubMed  Google Scholar 

  36. [36]

    Xiang BQ, He JB, Gao H, Luo ZY, Dai YY, Wang WY. Effects of dexmedetomidine on the levels of proinflammatory mediators IL-1β and TNF-α in pulmonary ischemia/reperfusion injury rats and the mechanisms. Zhongguo Yingyong Shenglixue Zazhi, 2017, 33(5): 415–419.

    PubMed  Google Scholar 

  37. [37]

    Huang XS, Lu T, Zhang ZY. The effect of TNF-α on peripheral nerve injury and subsequent rational pain. Zhongguo Shiyong Shenjing Jibing Zazhi, 2015, 18(5): 101–102.

    Google Scholar 

  38. [38]

    Li Y, Chen WT, Shen WD. Transcutaneous electrical acupoint stimulation affects postoperative pain and immune function in anorectal diseases. Sichuan Zhongyi, 2017, 35(8): 186–188.

    Google Scholar 

  39. [39]

    Lin YF, Yang W, Li YJ, Li Y, Tong QY, Ma W, Li YJ, Shen WD. Mechanism of acupoint transcutaneous electric stimulation on analgesic anesthesia in the patients undergoing general anesthesia anorectal operation. Zhongguo Zhen Jiu, 2017, 37(7): 747–752.

    PubMed  Google Scholar 

  40. [40]

    Chen WY, Li L, Wang HY, Jiang N. Effects of transcutaneous electrical acupoint stimulation for depression in late pregnancy and impacts on inflammatory cytokines. Zhen Ci Yan Jiu, 2018, 43(1): 43–47.

    Google Scholar 

  41. [41]

    Desantana JM, Santana-Filho VJ, Sluka KA. Modulation between high- and low-frequency transcutaneous electric nerve stimulation delays the development of analgesic tolerance in arthritic rats. Arch Phys Med Rehabil, 2008, 89(4): 754–760.

    PubMed  PubMed Central  Article  Google Scholar 

Download references

Acknowledgments

This work was supported by National Natural Science Foundation of China (国家自然科学基金, No. 81960908).

Author information

Affiliations

Authors

Corresponding author

Correspondence to Chen Ri-lan 陈日兰.

Additional information

Conflict of Interest

The authors declare that there is no conflict of interest.

Rights and permissions

Reprints and Permissions

About this article

Verify currency and authenticity via CrossMark

Cite this article

Kai-feng, D., Ri-lan, C., Zi-long, L. et al. Overview of reported transcutaneous electrical acupoint stimulation effects on pain mediators. J. Acupunct. Tuina. Sci. 19, 78–82 (2021). https://doi.org/10.1007/s11726-021-1229-9

Download citation

Keywords

  • Transcutaneous Electrical Nerve Stimulation
  • Acupoint Therapy
  • Pain
  • Analgesia
  • Mechanism
  • Review

【关键词】

  • 经皮神经电刺激
  • 穴位疗法
  • 疼痛
  • 镇痛
  • 机制
  • 综述

【中图分类号】

  • R245.9

【文献标志码】

  • A