Overview of reported transcutaneous electrical acupoint stimulation effects on pain mediators



Literatures on pain intervention with transcutaneous electrical acupoint stimulation (TEAS) were collected by searching the databases both in Chinese and English, and summarized to understand the research progress of TEAS effects on pain mediators in recent years. This will provide a more objective and scientific theoretical basis for clinical practice of TEAS to treat pain syndrome, thus promoting the clinical application of TEAS. Our literature analysis indicated that TEAS effectively regulated the release levels of various pain factors such as prostaglandin, 5-hydroxytryptamine, interleukins, substance P and tumor necrosis factor-α to achieve the analgesic effects by affecting the conduction pathways. TEAS is a safe, non-invasive and effective treatment for pain syndrome. However, further research is necessary due to the lack of rigor of the current clinical trial design.


通过检索中英文数据库获取有关经皮穴位电刺激干预痛证的相关文献, 并进行整理归纳, 从而了解近年 来经皮穴位电刺激对疼痛介质影响的研究进展, 为临床采用经皮穴位电刺激治疗痛证提供更客观、科学的理论依 据, 促进经皮穴位电刺激的临床应用。文献分析结果表明经皮穴位电刺激可有效调控前列腺素、5-羟色胺、白介 素、P 物质、肿瘤坏死因子α 等多种疼痛因子的释放水平, 影响其传导通路, 从而起到镇痛效果; 经皮穴位电刺 激是一种安全、无创、有效的痛证治疗手段。但当前临床试验设计欠严谨, 研究仍需进一步深入。

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This work was supported by National Natural Science Foundation of China (国家自然科学基金, No. 81960908).

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Correspondence to Chen Ri-lan 陈日兰.

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The authors declare that there is no conflict of interest.

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Kai-feng, D., Ri-lan, C., Zi-long, L. et al. Overview of reported transcutaneous electrical acupoint stimulation effects on pain mediators. J. Acupunct. Tuina. Sci. 19, 78–82 (2021). https://doi.org/10.1007/s11726-021-1229-9

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  • Transcutaneous Electrical Nerve Stimulation
  • Acupoint Therapy
  • Pain
  • Analgesia
  • Mechanism
  • Review


  • 经皮神经电刺激
  • 穴位疗法
  • 疼痛
  • 镇痛
  • 机制
  • 综述


  • R245.9


  • A