Isolation of fucoxanthin from Sargassum thunbergii and preparation of microcapsules based on palm stearin solid lipid core
- 70 Downloads
The objective of this study was to isolate fucoxanthin from Sargassum thunbergii and develop microcapsules with palm stearin as the solid lipid core for stability and efficient oral delivery of fucoxanthin. The microcapsules had smooth surfaces with the volume weighted mean diameter (d4.3) of 19.19 μm. Encapsulation efficiency and loading capacity of microcapsules with fucoxanthin were 98.3% and 0.04%, respectively. Moreover, the fucoxanthin in microcapsules presented higher stability than free fucoxanthin against light, humidity and temperature. Especially, the retention rates of fucoxanthin encapsulated in microcapsules reached 97.20% at 4°C, 92.60% at 25°C, 92.32% with the relative humidity of 33% and 92.60% in the dark. The cumulative amount of fucoxanthin released from microcapsules was 22.92% in simulated gastric fluid (SGF) and 56.55% in simulated intestinal fluid (SIF).
Keywordsfucoxanthin Sargassum thunbergii microcapsules palm stearin solid lipid core
Unable to display preview. Download preview PDF.
This work was supported by Public Science and Technology Research Funds Projects of Ocean (Grant No. 201505022), the National Natural Science Foundation of China NSFC-Shandong Joint Fund (U1406402-5), the National Natural Science Foundation of China (Grant No. 81671828), and the Taishan Scholar Program of China.
- Nomura M, Kamogawa H, Susanto E, et al. Seasonal variations of total lipids, fatty acid composition, and fucoxanthin contents of Sargassum horneri (Turner) and Cystoseira hakodatensis (Yendo) from the northern seashore of Japan. Journal of Applied Phycology, 2013, 25(4): 1159–1169CrossRefGoogle Scholar
- Yu Y, Zhang Q, Lu Z, et al. Small-scale spatial and temporal reproductive variability of the brown macroalga Sargassum thunbergii in contrasting habitats: A study on the island of Xiaoheishan, Changdao Archipelago, China. Estuarine, Coastal and Shelf Science, 2012, 112: 280–286CrossRefGoogle Scholar