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Isolation of fucoxanthin from Sargassum thunbergii and preparation of microcapsules based on palm stearin solid lipid core

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Abstract

The objective of this study was to isolate fucoxanthin from Sargassum thunbergii and develop microcapsules with palm stearin as the solid lipid core for stability and efficient oral delivery of fucoxanthin. The microcapsules had smooth surfaces with the volume weighted mean diameter (d4.3) of 19.19 μm. Encapsulation efficiency and loading capacity of microcapsules with fucoxanthin were 98.3% and 0.04%, respectively. Moreover, the fucoxanthin in microcapsules presented higher stability than free fucoxanthin against light, humidity and temperature. Especially, the retention rates of fucoxanthin encapsulated in microcapsules reached 97.20% at 4°C, 92.60% at 25°C, 92.32% with the relative humidity of 33% and 92.60% in the dark. The cumulative amount of fucoxanthin released from microcapsules was 22.92% in simulated gastric fluid (SGF) and 56.55% in simulated intestinal fluid (SIF).

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Acknowledgements

This work was supported by Public Science and Technology Research Funds Projects of Ocean (Grant No. 201505022), the National Natural Science Foundation of China NSFC-Shandong Joint Fund (U1406402-5), the National Natural Science Foundation of China (Grant No. 81671828), and the Taishan Scholar Program of China.

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Authors and Affiliations

  1. College of Marine Life Science, Ocean University of China, 5# Yushan Road, Qingdao, 266003, China

    Xuanxuan Wang, Fangqin Wang, Guixue Xia, Xiaojie Cheng, Ming Kong, Ya Liu, Chao Feng & Xiguang Chen

  2. Aquatic Product Processing & Quality Control Research Centre, Marine Biology Institute of Shandong Province, 7# Youyun Road, Qingdao, 266002, China

    Hongyan Li, Hongjun Liu & Ying Wang

  3. Laboratory for Marine Drug and Bioproduct, Qingdao National Laboratory for Marine Science and Technology, 1# Wenhai Road, Qingdao, 266200, China

    Xiguang Chen

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  1. Xuanxuan Wang
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  2. Hongyan Li
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  3. Fangqin Wang
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  4. Guixue Xia
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  5. Hongjun Liu
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  6. Xiaojie Cheng
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  7. Ming Kong
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  8. Ya Liu
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  9. Chao Feng
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  10. Xiguang Chen
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  11. Ying Wang
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Correspondence to Xiguang Chen or Ying Wang.

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Wang, X., Li, H., Wang, F. et al. Isolation of fucoxanthin from Sargassum thunbergii and preparation of microcapsules based on palm stearin solid lipid core. Front. Mater. Sci. 11, 66–74 (2017). https://doi.org/10.1007/s11706-017-0372-1

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  • DOI: https://doi.org/10.1007/s11706-017-0372-1

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