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Preparation and antibacterial activity of chitosan microshperes in a solid dispersing system

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Abstract

In this study, we investigated the interface contacting inhibition behaviors of chitosan against bacterial in the dispersing state. For that purpose, chitosan microspheres (CMs) in the dispersing state was prepared by the emulsification cross-linking method. The CMs had smooth surface and spherical shape with the diameter of about 124 µm. They were stable after sterilization at 121°C and 150 kPa for 20 min. The CMs had similar antibacterial activity to that of chitosan in the solution form. Their antibacterial activities increased with the increase of the CM concentration, while decreased with the increase of pH of the system. It was found that the CMs with the degree of deacetylation (DD) of 63.6% exhibited the highest antibacterial activity, while the CMs with the DD of 83.7% exerted the lowest antibacterial activity among the three tested samples.

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Authors and Affiliations

  1. College of Marine Life Science, Ocean University of China, Qingdao, 266003, China

    Ming Kong, Xi-guang Chen, Cheng-sheng Liu, Le-jun Yu & Qiu-xia Ji

  2. The Graduate School of Biotechnology, Korea University, Seoul, 136-701, Korea

    Ming Kong, Dong Su Cha & Hyun Jin Park

  3. Qingdao Technical College, Qingdao, 266071, China

    Yu-ping Xue

Authors
  1. Ming Kong
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  2. Xi-guang Chen
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  3. Yu-ping Xue
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  4. Cheng-sheng Liu
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  5. Le-jun Yu
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  6. Qiu-xia Ji
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  7. Dong Su Cha
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  8. Hyun Jin Park
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Correspondence to Xi-guang Chen.

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Kong, M., Chen, Xg., Xue, Yp. et al. Preparation and antibacterial activity of chitosan microshperes in a solid dispersing system. Front. Mater. Sci. China 2, 214–220 (2008). https://doi.org/10.1007/s11706-008-0036-2

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  • DOI: https://doi.org/10.1007/s11706-008-0036-2

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