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Micronization of curcumin with biodegradable polymer by supercritical anti-solvent using micro swirl mixer

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Abstract

Curcumin is a hydrophobic polyphenol compound exhibiting a wide range of biological activities such as anti-inflammatory, anti-bacterial, anti-fungal, anti-carcinogenic, anti-human immunodeficiency virus, and antimicrobial activity. In this work, a swirl mixer was employed to produce the micronized curcumin with polyvinylpyrrolidone (PVP) by the supercritical anti-solvent process to improve the bioavailability of curcumin. The effects of operating parameters such as curcumin/PVP ratio, feed concentration, temperature, pressure, and CO2 flow rate were investigated. The characterization and solubility of particles were determined by using scanning electron microscopy, Fourier Transform Infrared spectroscopy, and ultra-violet-visible spectroscopy. The result shows that the optimal condition for the production of curcumin/PVP particles is at curcumin/PVP ratio of 1:30, feed concentration of 5 mg·mL−1, temperature of 40 °C, pressure of 15 MPa, and CO2 flow rate of 15 mL·min−1. Moreover, the dissolution of curcumin/PVP particles is faster than that of raw curcumin.

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Acknowledgements

This research is supported by ASEAN University Network for Southeast Asia Engineering Education Development Network (AUN/SEED-Net) project through the Japan International Cooperation Agency (JICA) and the Precursory Research for Embryonic Science and Technology Program of the Japan Science and Technology Agency (JST).

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Authors and Affiliations

  1. Department of Chemical Engineering, Nagoya University, Nagoya, 464-8603, Japan

    Kimthet Chhouk

  2. Department of Chemical Engineering and Food Technology, Institute of Technology of Cambodia, Phnom Penh, Cambodia

    Kimthet Chhouk

  3. Department of Materials Process Engineering, Nagoya University, Nagoya, 464-8603, Japan

    Wahyudiono, Hideki Kanda & Motonobu Goto

  4. Research Institute for Chemical Engineering Process Technology, National Institute of Advanced Industrial Science and Technology, Sendai, 983-8551, Japan

    Shin-Ichro Kawasaki

Authors
  1. Kimthet Chhouk
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  2. Wahyudiono
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  3. Hideki Kanda
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  4. Shin-Ichro Kawasaki
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  5. Motonobu Goto
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Correspondence to Kimthet Chhouk or Motonobu Goto.

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Chhouk, K., Wahyudiono, Kanda, H. et al. Micronization of curcumin with biodegradable polymer by supercritical anti-solvent using micro swirl mixer. Front. Chem. Sci. Eng. 12, 184–193 (2018). https://doi.org/10.1007/s11705-017-1678-3

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  • DOI: https://doi.org/10.1007/s11705-017-1678-3

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