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Design, synthesis, and antiviral properties of 2-aryl-1H-benzimidazole-4-carboxamide derivatives

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Abstract

A series of new benzimidazole derivatives were designed and synthesized. Their chemical structures were testified by 1H NMR, infrared spectroscopy (IR), mass spectrography (MS), and elemental analysis. Their potent antiviral properties indicated the prospect of new drugs. Compound 13, 16, 18, 19, 21, 22, and 23 were identified as novel antivirus with much better selective activity and inhibitory activity than the comparable ribavirin against Coxsackie virus B3 in VERO cells.

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Authors and Affiliations

  1. School of Chemistry and Chemical Engineering, Shanghai Jiao Tong University, Shanghai, 200240, China

    Xianjin Luo, Zhonglü Zhang, Yutian Yang & Fei Xue

  2. Schools of Life Science and Environmental Science, Shanghai Normal University, Shanghai, 200234, China

    Naiyun Xiu

  3. Institute of Green Chemistry and Fine Chemicals, Beijing University of Technology, Beijing, 100022, China

    Yuanbin She

Authors
  1. Xianjin Luo
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  2. Zhonglü Zhang
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  3. Yutian Yang
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  4. Fei Xue
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  5. Naiyun Xiu
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  6. Yuanbin She
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Correspondence to Xianjin Luo.

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Luo, X., Zhang, Z., Yang, Y. et al. Design, synthesis, and antiviral properties of 2-aryl-1H-benzimidazole-4-carboxamide derivatives. Front. Chem. Eng. China 3, 305–309 (2009). https://doi.org/10.1007/s11705-009-0021-z

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  • DOI: https://doi.org/10.1007/s11705-009-0021-z

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