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Synthesis and antioxidant activity of monoterpene nitrobenzylidenesulfenimines

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Abstract

Novel nitrobenzylidenesulfenimines based on monoterpene hydroxythiols were synthesized with yields of 51–84% for the first time. The obtained compounds showed high antioxidant and membrane-protective activities in in vitro models.

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Acknowledgements

This work was partially supported by Russian Foundation for Basic Research (Project 19-03-00951) using equipment from the Center for Collective Usage "Chemistry" of the Institute of Chemistry of the Komi Scientific Center, Ural Branch of the Russian Academy of Sciences. The study of antioxidant and membrane-protective activities was performed using the equipment of the Center of Collective Usage “Molecular Biology” of the Institute of Biology of the Komi Scientific Center of the Ural Branch of the Russian Academy of Sciences at the expense of the state assignment (project No. AAAA-A18-118011120004-5). The used animals were taken from the scientific collection of experimental animals from the Institute of Biology of the Komi Scientific Center, Ural Branch of the Russian Academy of Sciences (https://www.ckp-rf.ru/usu/471933/).

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Correspondence to Denis V. Sudarikov.

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Sudarikov, D.V., Krymskaya, Y.V., Melekhin, A.K. et al. Synthesis and antioxidant activity of monoterpene nitrobenzylidenesulfenimines. Chem. Pap. 75, 2957–2963 (2021). https://doi.org/10.1007/s11696-020-01362-4

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  • DOI: https://doi.org/10.1007/s11696-020-01362-4

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