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Chemical Papers

, Volume 73, Issue 11, pp 2745–2748 | Cite as

Efficient synthesis of 5-bromo-2,3-dimethoxy-6-methyl-1,4-benzoquinone: key intermediate for preparing Coenzyme Q

  • Yong-Fu Qiu
  • Bin Lu
  • Yi-Yu Yan
  • Wan-Yue Luo
  • Jin WangEmail author
  • Xiao HuEmail author
Original Paper
  • 167 Downloads

Abstract

The title compound, a key intermediate for preparing Coenzyme Qn family, was prepared in an excellent yield by a reaction sequence starting from the commercially available 3,4,5-trimethoxytoluene 1 via bromination, methoxylation and oxidation reactions. An 80% overall yield was demonstrated on a multi-gram scale.

Keywords

Coenzyme Q 1,4-Benzoquinone Bromination 

Notes

Acknowledgements

This study was supported by the National Natural Science Foundation of China (nos. 31600740 and 81803353), the Natural Science Foundation of Jiangsu Province (BK20160443), the Six Talent Peaks Project in Jiangsu Province (SWYY-094), the Jiangsu Provincial Key Laboratory for Bioresources of Saline Soils (nos. JKLBS2016013 and JKLBS2017010) and the College students practice innovation training program of Yancheng Teachers University (Provincial key projects).

Supplementary material

11696_2019_826_MOESM1_ESM.doc (452 kb)
Supplementary material 1 (DOC 451 kb)

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Copyright information

© Institute of Chemistry, Slovak Academy of Sciences 2019

Authors and Affiliations

  1. 1.School of Pharmacy, Jiangsu Key Laboratory for Bioresources of Saline SoilsYancheng Teachers UniversityYanchengPeople’s Republic of China
  2. 2.Library of Yancheng Teachers UniversityYanchengPeople’s Republic of China

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