Abstract
A high performance liquid chromatography (HPLC) method with mass spectrometry (MS) detection coupled previously cloud point preconcentration was developed for the determination of nimesulide in synthetic urine. Non-ionic surfactants Triton X-100 and Triton X-114 were used for cloud point extraction (CPE) of nimesulide. Various influencing parameters on the CPE process, such as pH, the concentration of non-ionic surfactant, equilibration temperature, incubation time and centrifugation parameters were studied and optimized. The developed method was validated; the linear range was in the range 67–5000 ng mL−1, the detection (3σ) and quantification (10σ) limits were 20 ng mL−1 and 67 ng mL−1, respectively. The intra-day and inter-day precisions were less than 14%, the average recovery factors were in the range 95–117%. The suggested CPE–HPLC–MS method was simple and sensitive and could be an effective tool for the determination of nimesulide in biological samples.
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Makukha, O.G., Ivashchenko, L.A., Zaporozhets, O.A. et al. Cloud point extraction combined with HPLC–MS for the determination of nimesulide in biological samples. Chem. Pap. 73, 693–699 (2019). https://doi.org/10.1007/s11696-018-0618-0
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DOI: https://doi.org/10.1007/s11696-018-0618-0