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Enantioseparation of novel psychoactive chiral amines and their mixture by capillary electrophoresis using cyclodextrins as chiral selectors

  • Klára Řezanková
  • Radka Kohoutová
  • Martin Kuchař
  • Vladimír Král
  • Pavel Řezanka
Original Paper

Abstract

The prevalence of new psychoactive substances (NPS) has been increasing during the last decade as well as their constant growth of availability across the whole world. Regardless of the potential health hazard, NPS (often racemic compounds) are frequently sought after and abused for their psychoactive effects that may differ for individual enantiomers. In this work, capillary electrophoresis was used for the chiral separation of a mixture of eleven psychoactive chiral amines using β-cyclodextrin and carboxymethyl-β-cyclodextrin as chiral selectors at various concentrations. Chiral separation was successful for all the analytes studied. A mixture of these analytes was subsequently analyzed under optimal conditions, i.e., when using 20 mmol/L carboxymethyl-β-cyclodextrin in 50 mmol/L sodium phosphate buffer, pH 2.5. In this case, chiral separation occurred in nine out of eleven analytes. To our best knowledge, we achieved enantioseparations of seven analyzed compounds by CE for the first time.

Keywords

Capillary electrophoresis Chiral separation Enantioselectivity Psychoactive substances 

Notes

Acknowledgements

This work was supported by specific university research (MSMT no. 20-SVV/2018), by the “Operational Programme Prague—Competitiveness” (CZ.2.16/3.1.00/21537), by the “National Programme of Sustainability I”—NPU I (LO1601 no. MSMT-43760/2015), and by the Ministry of Interior of the Czech Republic, project no. VI20172020056.

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Copyright information

© Institute of Chemistry, Slovak Academy of Sciences 2018

Authors and Affiliations

  1. 1.Department of Analytical ChemistryUniversity of Chemistry and TechnologyPragueCzech Republic
  2. 2.Forensic Laboratory of Biologically Active SubstancesUniversity of Chemistry and TechnologyPragueCzech Republic
  3. 3.Department of Chemistry of Natural CompoundsUniversity of Chemistry and TechnologyPragueCzech Republic

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