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Chemical Papers

, Volume 72, Issue 11, pp 2813–2819 | Cite as

Design and synthesis of an AIE-active fluorogen with red emission and its biological application

  • Lufei XiaoEmail author
  • Hongji Sun
  • Le Zhou
  • Di Li
  • Hui WangEmail author
Original Paper
  • 274 Downloads

Abstract

A novel triphenylamine-base derivative L containing pyridine and terpyridine was designed and synthesized. Compound L exhibited distinct aggregation-induced emission (AIE) behavior in water–ethanol and also displayed a threefold increase in the intensity of luminescence at 608 nm. Furthermore, confocal microscopy imaging demonstrated that compound L displays low toxicity and brights red fluorescence in mitochondria in living HepG2 cells. Inherent from the mitochondrial-targeting ability of pyridine moiety and the AIE characteristic of triphenylamine group, compound L could be employed as a fluorescent probe in the near-infrared region for living cell imaging.

Keywords

Aggregation-induced enhanced emission Triphenylamine Mitochondria Pyridine 

Notes

Acknowledgements

This study was supported by the Science Foundation of Department Education of Anhui Province (KJ2017ZD49), and the Talent Foundation of the Education Department of Anhui (gxbjZD2016111), Doctoral Startup Foundation of Wannan Medical College (wYRCQD201715).

Supplementary material

11696_2018_529_MOESM1_ESM.docx (3.3 mb)
Supplementary material 1 (DOCX 3356 kb)

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Copyright information

© Institute of Chemistry, Slovak Academy of Sciences 2018

Authors and Affiliations

  1. 1.Department of Food and Environmental EngineeringChuzhou Vocational and Technical CollegeChuzhouPeople’s Republic of China
  2. 2.Department of ChemistryWannan Medical CollegeWuhuPeople’s Republic of China
  3. 3.Anhui Province Key Laboratory of Active Biological Macro-molecules ResearchWannan Medical CollegeWuhuPeople’s Republic of China

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