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Chemical Papers

, Volume 72, Issue 11, pp 2753–2768 | Cite as

Microwave promoted synthesis and anticological screening of β-aminobisphosphonates-based benzothiazole motif against human breast and colon cancer diseases

  • Wafaa M. AbdouEmail author
  • Maha D. Khidre
  • Abeer A. Shaddy
Original Paper

Abstract

New antineoplastic series of substituted benzothiazolo-β-aminobisphosphonic acids have been developed on the basis of the prospecting potency of the benzothiazole motifs and the aminomethylenebisphosphonate moiety as well as on the prediction of the biological activity utilizing computer program PASS, version 2014-1. Target compounds were obtained in excellent yields (70–90%) via Phospha–Michael-type addition reaction of tetraethyl methylene-1,1-bisphosphonate reagent to a group of Schiff bases incorporating benzothiazole moiety. The reactions proceeded under microwave irradiation, utilizing the advantages of the environment, friendly protocol such as high efficiency, short reaction time, and excellent yields. In consistency with the prospected results, the new NBP acids revealed positive properties against human breast and colon tumor cell lines. Remarkable potency for six lead compounds (out of 12) was observed against breast (MCF7, MDAMB/435, MDAMB/231/ATCC, HS-578T with GI50: 2.05–6.47 μM) and colon (COLO-205, HCT-116, HCC-2998, and SW-620 with GI50: 3.03–7.92 μM) carcinoma cell lines when compared with the positive control Adriamycin (breast, GI50: 3.27–6.64 μM; colon, GI50: 4.09–8.75 μM). Notably, there is a consistency between the prediction and the determined biological results.

Keywords

β-Aminobisphosphonates Benzothiazoles Antitumor agents Phospha–Michael addition Structure activity relationships 

Notes

Acknowledgements

Authors like to thank the National Research Centre, Dokki, Cairo, Egypt (project # 10010340) for the financial support of the present work. They also are grateful to Cancer Research Institute, NY, USA, for handling the antitumor properties.

Supplementary material

11696_2018_505_MOESM1_ESM.rar (827 kb)
Supplementary material 1 (RAR 826 kb)

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Copyright information

© Institute of Chemistry, Slovak Academy of Sciences 2018

Authors and Affiliations

  1. 1.Chemical Industries DivisionNational Research CentreDokkiEgypt

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