Synthesis, antibacterial, and antiviral activities of novel penta-1,4-dien-3-one derivatives containing a benzotriazin-4(3H)-one moiety

  • Ju-Ping Zhang
  • Qin Li
  • Cheng Zhang
  • Pu Li
  • Li-Juan Chen
  • Yi-Hui Wang
  • Xiang-Hui Ruan
  • Wei Xiao
  • Wei Xue
Original Paper
  • 28 Downloads

Abstract

A series of penta-1,4-dien-3-one containing a benzotriazin-4(3H)-one moiety were prepared and evaluated for their antibacterial and antiviral activities. Bioassays indicated that some compounds exhibited good antibacterial and antiviral activities. Among them, the EC50 values of compound 6d against Xanthomonas axonopodis pv. citri and compound 6l against Ralstonia solanacearum were, respectively, 22.45 and 34.77 μg/mL, which were better than that of thiodiazole copper (51.35 and 87.26 μg/mL, respectively). Meanwhile, some title compounds were found to show remarkable antiviral activities against tobacco mosaic virus (TMV). These results indicated that penta-1,4-dien-3-one derivatives containing benzotriazin-4(3H)-one moiety could play significant roles in searching for novel agrochemicals.

Keywords

Penta-1,4-dien-3-one Antiviral Antibacterial Benzotriazin-4(3H)-one 

Notes

Acknowledgements

This research was supported by the National Key Research and Development Program of China (No. 2017YFD0200506), the National Nature Science Foundation of China (No. 21462012), the Special Fund for Outstanding Scientific and Technological Candidates of Guizhou Province (No. 201535), and the Innovation Fund for Graduate Student of Guizhou University (No. 2017059).

Supplementary material

11696_2018_422_MOESM1_ESM.doc (2.1 mb)
Supplementary material 1 The 1H NMR, 13C NMR, and HRMS spectrum data of the compounds were listed in the supporting information. (DOC 2178 kb)

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Copyright information

© Institute of Chemistry, Slovak Academy of Sciences 2018

Authors and Affiliations

  • Ju-Ping Zhang
    • 1
  • Qin Li
    • 1
  • Cheng Zhang
    • 1
  • Pu Li
    • 1
  • Li-Juan Chen
    • 1
  • Yi-Hui Wang
    • 1
  • Xiang-Hui Ruan
    • 1
  • Wei Xiao
    • 1
  • Wei Xue
    • 1
  1. 1.State Key Laboratory Breeding Base of Green Pesticide and Agricultural Bioengineering, Key Laboratory of Green Pesticide and Agricultural Bioengineering, Ministry of EducationGuizhou UniversityGuiyangChina

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