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Synthesis of trisubstituted furans via Ag-catalyzed cascade heterocyclization of 2-(1-alkynyl)-2-alken-1-ones with aryl-amines

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Abstract

A silver(I)-catalyzed cascade heterocyclization of 2-(1-alkynyl)-2-alken-1-ones with aryl-amines is described to synthesize trisubstituted furans in moderate to good yields. Tertiary amine is also efficient in this reaction. This transformation proceeds smoothly with the formation of C–N or C–C bonds in one-pot with good functional group tolerance under mild conditions.

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Acknowledgements

The authors gratefully acknowledge the National Natural Science Foundation of China (NSFC 20967006) and Qinghai Normal University (15RZ12) for financial support.

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Authors and Affiliations

  1. School of Chemistry and Chemical Engineering, Qinghai Normal University, Xining, 810008, People’s Republic of China

    Ting He, Yaling Chi & Yuantao Chen

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  1. Ting He
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  2. Yaling Chi
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  3. Yuantao Chen
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Correspondence to Ting He or Yuantao Chen.

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He, T., Chi, Y. & Chen, Y. Synthesis of trisubstituted furans via Ag-catalyzed cascade heterocyclization of 2-(1-alkynyl)-2-alken-1-ones with aryl-amines. Chem. Pap. 72, 691–696 (2018). https://doi.org/10.1007/s11696-017-0323-4

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