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Tetracoordinate cobalt(II) complexes with neocuproine: single-molecule magnets with potential biological activity

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Abstract

Interaction of two mononuclear tetracoordinate complexes [Co(dmphen)Br2] and [Co(dmphen)I2] (dmphen = 2,9-dimethyl-1,10-phenanthroline), which have been recently reported to behave as single-molecule magnets (SMMs) in an applied external field, with calf thymus (CT) DNA in solution was studied by spectral methods (UV–Vis, fluorescence, and circular dichroism). Results indicate that both complexes along with their chlorido analogue [Co(dmphen)Cl2] are able to bind with the CT DNA via intercalation, with the values of Stern–Volmer constants obtained from the linear quenching plot in range of 1.86 × 104–2.11 × 104 M−1. Furthermore, Topoisomerase I inhibition studies suggest that all three complexes exhibit inhibition activity at concentrations of 45 μM.

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Acknowledgements

This work was financially supported by Slovak grant agencies (APVV-14-0078 and VEGA 1/0131/16 and 1/0063/17). LS acknowledges support of postdoctoral Grant of P. J. Šafárik University in Košice (I-12-0001-13).

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Authors and Affiliations

  1. Department of Medical and Clinical Biochemistry, P.J. Šafárik University in Košice, Trieda SNP 1, 04154, Košice, Slovakia

    Lukáš Smolko

  2. Department of Inorganic Chemistry, P.J. Šafárik University in Košice, Moyzesova 11, 04154, Košice, Slovakia

    Juraj Černák & Juraj Kuchár

  3. Department of Biochemistry, P.J. Šafárik University in Košice, Moyzesova 11, 04154, Košice, Slovakia

    Danica Sabolová

  4. Department of Chemistry, University of SS Cyril and Methodius, Nám. J. Herdu 2, 91707, Trnava, Slovakia

    Roman Boča

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  1. Lukáš Smolko
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  2. Juraj Černák
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  3. Juraj Kuchár
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  4. Danica Sabolová
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  5. Roman Boča
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Correspondence to Lukáš Smolko.

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This article belongs to the “Coordination and Bioinorganic Conference”.

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Smolko, L., Černák, J., Kuchár, J. et al. Tetracoordinate cobalt(II) complexes with neocuproine: single-molecule magnets with potential biological activity. Chem. Pap. 72, 877–882 (2018). https://doi.org/10.1007/s11696-017-0322-5

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  • DOI: https://doi.org/10.1007/s11696-017-0322-5

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