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RETRACTED ARTICLE: Design, synthesis of novel oxazolidino-amides/sulfonamides conjugates and their impact on antibacterial activity

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This article was retracted on 11 November 2021

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Abstract

In view of generating new compounds for future drug development, we have synthesized oxazolidinones library of aryl amides and aryl sulfonamide derivatives. These compounds were screened in vitro against panel of susceptible and resistant Gram-positive (Staphylococcus aureus and Bacillus subtilis), Gram-negative bacteria (Pseudomonas aeruginosa), fungi (Candida albicans) strains, and Mycobacterium tuberculosis (Mtb). Among them, 10d and 11a compounds have been evaluated against 12 fungal strains and have displayed significant antimycotic activities approximately 37 folds more potent than fluconazole.

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Author information

Authors and Affiliations

  1. Division of Chemistry, Department of Sciences and Humanities, Vignan’s Foundation for Science, Technology and Research University (VFSTR University), Vadlamudi, Guntur, 522 213, Andhra Pradesh, India

    Yarlagadda Bharath

  2. Department of Pharmacy, Osmania University, Hyderabad, Telangana, India

    Gopi Reddy Alugubelli

  3. Department of Chemistry, University College of Engineering (Autonomous), Jawaharlal Nehru Technological University, Kakinada, 533 003, Andhra Pradesh, India

    Reddymasu Sreenivasulu

  4. Department of Chemistry, Dr. MRAR. PG Centre, Krishna University, Nuzvid, 521 201, Andhra Pradesh, India

    Mandava. V. Basaveswara Rao

Authors
  1. Yarlagadda Bharath
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  2. Gopi Reddy Alugubelli
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  3. Reddymasu Sreenivasulu
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  4. Mandava. V. Basaveswara Rao
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Contributions

M.V.B.Rao and R.S designed and supervised the study, Y.B synthesized and characterized compounds, and measured spectral data, biological activity was carried at CCMB (The Centre for Cellular & Molecular Biology, Hyderabad).

Corresponding author

Correspondence to Mandava. V. Basaveswara Rao.

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Bharath, Y., Alugubelli, G.R., Sreenivasulu, R. et al. RETRACTED ARTICLE: Design, synthesis of novel oxazolidino-amides/sulfonamides conjugates and their impact on antibacterial activity. Chem. Pap. 72, 457–468 (2018). https://doi.org/10.1007/s11696-017-0298-1

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  • DOI: https://doi.org/10.1007/s11696-017-0298-1

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