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Flavonoids from Cirsium japonicum var. maackii pappus as inhibitors of aldose reductase and their simultaneous determination

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An Erratum to this article was published on 22 August 2017

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Abstract

Aldose reductase is an enzyme in the polyol pathway which is associated in the progression of diabetic complications. In this study, we evaluated the inhibitory activity of Cirsium japonicum var. maackii pappus (CJP) against rat lens aldose reductase (RLAR). The ethanolic extract, fractions and isolated flavonoids were subjected to an RLAR assay. Isolation of chloroform (CHCl3) and ethyl acetate (EtOAc) fractions led to the identification of four flavonoids: hispidulin (1), cirsimaritin (2), apigenin (3), and cirsimarin (4). The RLAR assay results suggested that the EtOAc fraction and flavonoids 1 and 3 promoted better AR inhibition than did TMG (control). The half-maximal inhibitory concentration (IC50) of compounds 1 and 3 was 0.77 and 3.19 μM, respectively. A simultaneous determination of flavonoid content using HPLC–UV indicated that CJP contained large amounts of compounds 2 and 3 (1.65 and 1.84 mg/g, respectively). Flavonoids from Cirsium species have been widely reported to show various pharmacological activities. This study indicated that CJP has the potential to prevent diabetic complications and was a potential source of flavonoids.

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  • 22 August 2017

    An erratum to this article has been published.

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Acknowledgements

This work was supported by the Chung-Ang University Research Grants in 2017 and by the grant from Imsil Herbal Medicine, Imsil, Republic of Korea.

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Authors and Affiliations

  1. Department of Integrative Plant Science, Chung-Ang University, Anseong, 17546, Republic of Korea

    Joyce P. Rodriguez, Yoon Kyoung Lee & Sanghyun Lee

  2. Sejong Academy of Science and Arts, Sejong, 30099, Republic of Korea

    Dong Geon Woo

  3. Imsil Herbal Medicine, Imsil, 55955, Republic of Korea

    Jae Suk Shim

  4. Department of Biology, University of San Carlos, 6000, Cebu, Philippines

    Paul John L. Geraldino

  5. Institute of Biology, University of the Philippines, Diliman, 1101, Quezon City, Philippines

    Sonia D. Jacinto

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  1. Joyce P. Rodriguez
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  2. Yoon Kyoung Lee
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Corresponding author

Correspondence to Sanghyun Lee.

Additional information

The original version of this article was revised: The spelling of the forth author was incorrect. The correct name is Jae Suk Shim. In Material and methods, Plant material, first sentence: the date was incorrect. The correct date is October 2014.

An erratum to this article is available at https://doi.org/10.1007/s11696-017-0271-z.

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Rodriguez, J.P., Lee, Y.K., Woo, D.G. et al. Flavonoids from Cirsium japonicum var. maackii pappus as inhibitors of aldose reductase and their simultaneous determination. Chem. Pap. 72, 81–88 (2018). https://doi.org/10.1007/s11696-017-0259-8

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