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Study of the structure, prooxidative, and cytotoxic activity of some chelate copper(II) complexes

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Abstract

The six chelate N,O-copper(II) complexes were synthesised starting from salicylaldehyde anil Schiff bases, as ligands. Their structure is elucidated using experimental and theoretical tools. In vitro biological activities, i.e. cytotoxic and prooxidative effects against human epithelial mammary gland/breast metastatic carcinoma MDA-MB-231, epithelial colorectal carcinoma HCT-116, and foetal lung fibroblast healthy MRC-5 cell lines of investigated compounds are also determined. Complexes Cu-1, Cu-6, and especially Cu-7 showed significant cytotoxic effects, with IC50 values comparable with effects of positive control CisPt. In addition, investigated complexes induced extreme oxidative and nitrosative stress in all treated cell lines. The most prominent effect is observed on HCT-116 cells, and on MRC-5 cells, while MDA-MB-231 cells showed higher resistance to the investigated cell lines, giving us direction towards the substances with more specific selectivity.

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Acknowledgements

This work was supported by the Ministry of Education, Science and Technological Development of the Republic of Serbia (Projects No. 172016, III41010).

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  1. Department of Chemistry, Faculty of Science, University of Kragujevac, Radoja Domanovića 12, Kragujevac, 34000, Serbia

    Vladimir P. Petrović, Dušica Simijonović, Jelena Đorović & Zorica D. Petrović

  2. Department of Biology and Ecology, Faculty of Science, University of Kragujevac, Radoja Domanovića 12, Kragujevac, 34000, Serbia

    Marko N. Živanović & Snežana D. Marković

  3. Bioengineering Research and Development Center, Kragujevac, 34000, Serbia

    Jelena Đorović

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  1. Vladimir P. Petrović
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Correspondence to Vladimir P. Petrović.

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Petrović, V.P., Živanović, M.N., Simijonović, D. et al. Study of the structure, prooxidative, and cytotoxic activity of some chelate copper(II) complexes. Chem. Pap. 71, 2075–2083 (2017). https://doi.org/10.1007/s11696-017-0200-1

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