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Chemical Papers

, Volume 71, Issue 1, pp 41–48 | Cite as

Secondary metabolites, antioxidant and anti-proteinase activities of methanolic extracts from cones of hop (Humulus lupulus L.) cultivars

  • Tibor Maliar
  • Peter Nemeček
  • Eva Ürgeová
  • Mária Maliarová
  • Vladimír Nesvadba
  • Karel Krofta
  • Katarína Vulganová
  • Erik Krošlák
  • Ján KraicEmail author
Original Paper

Abstract

Contents of polyphenols, flavonoids, bitter acids, α-bitter acids, xanthohumol, desmethylxanthohumol, essential oils, antioxidant activities, and inhibitory activities against trypsin, thrombin, urokinase, and papain were analysed in methanolic extracts prepared from the hope cones. Significant differences between extracts from eight hop cultivars in all measured parameters were found. Two cultivars—Agnus and Vital—could be designated as the very special, all possessing high content of bitter acids, α-acids, essential oils, xanthohumol, and desmethylxanthohumol. The other two cultivars—Bohemie and Sládek—had interesting inhibitory activities against analysed proteinases. Differences between cultivars were also in content of total polyphenols, total flavonoids, as well as in antioxidant activity. All analysed hop cultivars developed originally for brewing contained also secondary metabolites with valuable biological activities related to health conditions associated with antioxidant status and some pathophysiological agents of proteinase character.

Keywords

Humulus lupulus Secondary metabolites Polyphenols Flavonoids Antioxidant activity Proteinase inhibition 

Notes

Acknowledgements

This work was supported by the Grant No. VEGA 1/0635/13 “Hop as an important source of phytomedically active substances” supported by the Scientific Grant Agency of the Slovak Academy of Sciences and Ministry of Education, Science, Research and Sport of the Slovak Republic.

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Copyright information

© Institute of Chemistry, Slovak Academy of Sciences 2016

Authors and Affiliations

  • Tibor Maliar
    • 1
  • Peter Nemeček
    • 2
  • Eva Ürgeová
    • 3
  • Mária Maliarová
    • 2
  • Vladimír Nesvadba
    • 4
  • Karel Krofta
    • 4
  • Katarína Vulganová
    • 5
  • Erik Krošlák
    • 1
  • Ján Kraic
    • 1
    Email author
  1. 1.Department of Biotechnology, Faculty of Natural SciencesUniversity of SS. Cyril and MethodiusTrnavaSlovak Republic
  2. 2.Department of Chemistry, Faculty of Natural SciencesUniversity of SS. Cyril and MethodiusTrnavaSlovak Republic
  3. 3.Department of Biology, Faculty of Natural SciencesUniversity of SS. Cyril and MethodiusTrnavaSlovak Republic
  4. 4.Hop Research Institute, Co., Ltd.ŽatecCzech Republic
  5. 5.Institute the Physiotherapy, Balneology and Therapeutic RehabilitationUniversity of SS, Cyril and MethodiusTrnavaSlovak Republic

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