C Peptide Fails to Improve the Utility of the DiaRem Algorithm in Predicting Remission of Type II Diabetes After Bariatric Surgery


We evaluated the utility of C peptide as an addition to the DiaRem score for predicting type 2 diabetes (T2D) remission 1 year after bariatric surgery in 175 patients. DiaRem score was significantly correlated with C peptide (r = − .43; p < .001). Both DiaRem and C peptide were significant predictors of remission of T2D (OR (95% CI) = .81 (.75–.86); p < 0001 and OR (95% CI) = 1.35 (1.15–1.60); p < .001, respectively). ROC analysis indicated that DiaRem was a significantly stronger predictor than C peptide (p < .001). Hierarchical regression indicated that C peptide failed to significantly improve the prediction of diabetes remission after accounting for DiaRem (OR (95% CI) = 1.079 (.87–1.26); p = .406). This study does not support the inclusion of C peptide in the DiaRem algorithm.

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Corresponding author

Correspondence to Pavlos K. Papasavas.

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Conflict of Interest

RLS: no conflict of interest. TM: no conflict of interest. MO: no conflict of interest. IS: no conflict of interest. AS: no conflict of interest. DU: no conflict of interest. DT served as a consultant for Olympus, Medtronic, Conmed and Intuitive. PKP: no conflict of interest.

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Seip, R.L., McLaughlin, T., O’Brien, M. et al. C Peptide Fails to Improve the Utility of the DiaRem Algorithm in Predicting Remission of Type II Diabetes After Bariatric Surgery. OBES SURG (2021). https://doi.org/10.1007/s11695-021-05227-x

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  • DiaRem
  • Sleeve gastrectomy
  • Gastric bypass
  • Gastric banding
  • Diabetes