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Long-Term Changes in Leptin, Chemerin, and Ghrelin Levels Following Roux-en-Y Gastric Bypass and Laparoscopic Sleeve Gastrectomy

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Abstract

Aim

Published reports showed conflicting results regarding the sustained alterations in leptin, chemerin, and ghrelin concenratios after metabolic surgery. Therefore, we performed the present work to contrast the alterations in leptin, chemerin, and ghrelin levels one year after Roux-en-Y gastric bypass (RYGB) versus laparoscopic sleeve gastrectomy (LSG).

Methods

The present research is a prospective, comparative one that followed 100 cases for whom RYGB or LSG was done. We assessed the serum values of adiposity-associated mediators, including adipokcytokines (leptin and active chemerin) and gastrointestinal hormones (total ghrelin). The primary outcome in the present study was the alterations in leptin, chemerin, and ghrelin values at 12 months after RYGB and LSG.

Results

The serum leptin level decreased significantly in the LSG group with a mean change of − 170.8 ± 29.4 ng/mL (p < 0.001). Similarly, the serum leptin concentration decreased significantly in the RYGB group, with a mean change of − 165.42 ± 53.4 (p < 0.001). In addition, the mean reduction in baseline chemerin levels 12 months after the operation was considerable in the LSG cohort (− 23.24 ± 9.5 ng/mL) and RYGB group (− 22.12 ± 15.9 ng/mL). The ghrelin values demonstrated a notable reduction in the LSG cohort (− 0.083 ± 0.11 pg/mL) and RYGB group (− 0.068 ± 0.097 pg/mL). However, the changes in the three hormones were not substantially different between both groups (p > 0.05).

Conclusion

Both RYGB and LSG result in a considerable, comparable decrease in the postoperative serum concentrations of leptin, chemerin, and ghrelin.

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Authors and Affiliations

  1. General Surgery Department, Faculty of Medicine, Cairo University, Giza, 11311, Egypt

    Mohamed Abdalla Salman, Ahmed Abdallah & Hani Maurice Sabri Mikhail

  2. Internal Medicine Department, Faculty of Medicine, Cairo University, Giza, Egypt

    Mohamed El-ghobary, Ahmed Soliman, Mohammad El Sherbiny, Tarek Elsayed Abouelregal, Amr Albitar & Ahmed Abdallah Salman

  3. General Surgery Department, Faculty of Medicine, Al Azhar University, Cairo, Egypt

    Mohammed A Nafea & Ahmed Abd El Aal Sultan

  4. General Surgery Department, Faculty of Medicine, Helwan University, Helwan, Egypt

    Hossam E Elshafey

  5. National Hepatology and Tropical Medicine Research Institute, Cairo, Egypt

    Hossam El-Din Shaaban

  6. Clinical Biochemistry Department, National Liver Institute, Menoufia University, Shibin el Kom, Egypt

    Ayman Azzam

  7. Medical Biochemistry Department, Faculty of Medicine, Menoufia University, Shibin el Kom, Egypt

    Ghada M. K. GabAllah

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  1. Mohamed Abdalla Salman
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Correspondence to Ahmed Abdallah Salman.

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Informed consents were obtained from all patients included in the study

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The authors declare that they have no conflict of interest.

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This study was approved by the institutional review board/clinical medical research ethics committee.

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Salman, M.A., El-ghobary, M., Soliman, A. et al. Long-Term Changes in Leptin, Chemerin, and Ghrelin Levels Following Roux-en-Y Gastric Bypass and Laparoscopic Sleeve Gastrectomy. OBES SURG 30, 1052–1060 (2020). https://doi.org/10.1007/s11695-019-04254-z

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