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Analysis of Predictors of Type 2 Diabetes Mellitus Remission After Roux-en-Y Gastric Bypass in 101 Chinese Patients

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Abstract

Background

To investigate prognostic factors for complete remission in type 2 diabetes mellitus (T2DM) patients who underwent gastric bypass (GBP) and to establish a prognostic model for risk stratification.

Methods

We evaluated the baseline clinical features of patients with T2DM who received at Beijing Tian Tan Hospital from April 2012 to December 2015. Complete remission of T2DM was defined as meeting the following criteria: HbA1c < 6.5%, fasting plasma glucose (FPG) < 100 mg/dL, and absence of hypoglycemic drugs for 1 year following GBP.

Results

A total of 101 patients were enrolled in our study, and the complete remission rate of T2DM was 70.3% (71/101). Compared with patients with incomplete remission, patients with complete remission of T2DM had higher C-peptide levels, lower HbA1c, shorter disease duration, better β cell function, and an absence of insulin therapy. HbA1c level, fasting C-peptide, duration of T2DM, and history of medical therapy were important prognostic factors for complete remission of T2DM (P = 0.001, 0.002, 0.01, 0.028, respectively). Patients with HbA1c lower than 7.5%, a history of T2DM shorter than 9.5 years, fasting C-peptide higher than 1.2 ng/mL, and absence of insulin therapy before GBP achieved a higher complete remission rate of T2DM after GBP (AUC of the model was 0.825, 95% CI, 0.741–0.910; P = 0.001).

Conclusions

The duration of T2DM, history of medical therapy, and levels of HbA1c and fasting C-peptide are independent predictors for the prognosis of T2DM patients undergoing GBP. Patients with HbA1c lower than 7.5%, a history of T2DM shorter than 9.5 years, a fasting C-peptide higher than 1.2 ng/mL, and an absence of insulin therapy may have a higher complete remission rate of T2DM after GBP.

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Funding

This study was supported by “Beijing Municipal Science and Technology Commission” (Grant No. Z161100000116068).

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Authors and Affiliations

  1. Department of General Surgery, Beijing TianTan Hospital, Capital Medical University, NO. 119 South Fourth Ring Road West, Fengtai District, Beijing, 100070, People’s Republic of China

    Wenmao Yan, Rixing Bai, Youguo Li, Jun Xu, Zhiqiang Zhong, Ying Xing, Ming Yan, Yi Lin & Maomin Song

Authors
  1. Wenmao Yan
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  2. Rixing Bai
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  3. Youguo Li
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  4. Jun Xu
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  6. Ying Xing
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  7. Ming Yan
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  8. Yi Lin
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  9. Maomin Song
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Contributions

Rixing Bai and Maomin Song designed and supervised the study, Wenmao Yan collected and analyzed the data, and drafted the manuscript, Youguo Li, Jun Xu and Zhiqiang Zhong offered the technical or material support, Ying Xing, Yi Lin, Ming Yan and Maoming Song revised the manuscript for important intellectual content, all authors have read and approved the final version to be published.

Corresponding author

Correspondence to Rixing Bai.

Ethics declarations

All procedures performed in the study involving human participants were in accordance with the ethical standards of the institutional research committee and with the 1964 Helsinki Declaration and its later amendments or comparable ethical standards. All patients signed a written informed consent before LRYGB.

Conflict of Interest

The authors declare that they have no conflict of interest.

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Yan, W., Bai, R., Li, Y. et al. Analysis of Predictors of Type 2 Diabetes Mellitus Remission After Roux-en-Y Gastric Bypass in 101 Chinese Patients. OBES SURG 29, 1867–1873 (2019). https://doi.org/10.1007/s11695-019-03783-x

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  • DOI: https://doi.org/10.1007/s11695-019-03783-x

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