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The Effects of Laparoscopic Sleeve Gastrectomy on Obesity-Related Hypertriglyceridemia-Induced Acute Pancreatitis

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Abstract

Background

Hypertriglyceridemia-induced acute pancreatitis (HTG-AP) is a significant clinical problem and is characterized by high recurrence rate compared with non-HTG-AP. The objective of this study was to investigate the effects of laparoscopic sleeve gastrectomy (LSG) on obesity-related HTG-AP.

Methods

Twenty-nine patients with obesity-related HTG-AP were admitted to our hospital and treated with the conventional therapy or LSG surgery according to the wishes of patients. Clinical data and the recurrence rate of AP were collected at baseline and at four different time points (3, 6, 9, and 12 months) after the treatments for all patients.

Results

Of the 29 patients, 28 patients (19 patients with conventional therapy and 9 patients with LSG surgery) completed the 12-month follow-up. Clinical data and the severity scores of AP were comparable at baseline when the patients were admitted to the intensive care unit. The LSG group experienced a large weight loss (percent total weight loss, 26.87 ± 1.44%; percent excess weight loss, 79.56 ± 1.37%) and triglyceride reduction (from 15.77 ± 1.02 to 1.36 ± 0.09 mmol/L), and no recurrence was observed at 12 months after the surgery. In the conventional treatment group, however, body weight was not changed although triglyceride was significantly decreased (from 17.34 ± 1.29 to 8.25 ± 1.12 mmol/L), and more importantly, 47.4% of the patients had at least one recurrence of AP in 12 months after the treatment.

Conclusions

LSG might be an effective way to cure obesity-related HTG-induced AP since it prevents the recurrence of this disease. Further randomized studies will be needed to standardize this way of treatment.

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Funding

This research was supported by the National Natural Science Foundation of China (81500396), Foundation of Sichuan Educational Committee (18CZ0023, 17ZA0172), Foundation of Sichuan Health and Family Planning Commission (18PJ496), and Foundation of North Sichuan Medical College (CBY15-QD001).

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Authors and Affiliations

  1. School of Preclinical Medicine, North Sichuan Medical College, Nanchong, 637000, People’s Republic of China

    Yongyan Song

  2. School of Medical Imaging, North Sichuan Medical College, Nanchong, 637000, People’s Republic of China

    Huan Deng

  3. Department of General Surgery, Institute of Hepato-Biliary-Pancreas and Intestinal Disease, Affiliated Hospital of North Sichuan Medical College, Nanchong, 637000, People’s Republic of China

    Jie Zhou, Ji Sun & Yixing Ren

  4. Sichuan Key Laboratory of Medical Imaging, Department of Radiology, Affiliated Hospital of North Sichuan Medical College, Nanchong, 637000, People’s Republic of China

    Xiaoming Zhang

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  1. Yongyan Song
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  2. Huan Deng
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  4. Ji Sun
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Correspondence to Yixing Ren.

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The authors declare that they have no conflict of interest.

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All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional and/or national research committee and with the 1964 Helsinki declaration and its later amendments or comparable ethical standards.

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Informed consent was obtained from all individual participants included in the study.

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Song, Y., Deng, H., Zhou, J. et al. The Effects of Laparoscopic Sleeve Gastrectomy on Obesity-Related Hypertriglyceridemia-Induced Acute Pancreatitis. OBES SURG 28, 3872–3879 (2018). https://doi.org/10.1007/s11695-018-3446-y

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